Adenovirus expressing p27kip1 suppresses growth of established esophageal carcinoma xenografts

Figure 1 The growth curves of tumor.

Figure 2 Growth suppression of Ad-p27^kip1 on established esophageal carcinoma xenografts. 1: control group; 2: Ad-LacZ group; 3: Ad-p27^kip1 group.

Figure 3 Hematoxylin and eosin (H&E) staining of established esophageal carcinoma xenografts (×200).

Figure 4 Result of immunohistochemical staining of tumors in nude mice. A: control group. p27^kip1 protein located in cytoplasm of a few cells showing low expression; B: Ad-LacZ group. The result showed low expression also; C: Ad-p27^kip1 group. p27^kip1 protein located in cytoplasm and nucleus showing high expression (×200).

Figure 5 Result of immunohistochemical staining of tumors in nude mice. A: control group. Survivin protein located in cytoplasm showing high expression; B: Ad-LacZ group. The result showed high expression also; C: Ad-p27^kip1 group. Survivin protein located in cytoplasm of a few cells showing low expression (×200).