Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection

Figure 1 Frequency of the TT genotype at position -159 of the CD14 gene in patients with chronic hepatitis C infection, chronic alcohol abuse, and controls. The TT genotype was significantly more frequent in alcoholics with cirrhosis (25/62; [40.3%]), compared to alcoholics without clinical or sonomorphological signs of cirrhosis (28/118; [23.7%]; P = 0.020) and controls (55/247 [22.3%]; P = 0.006). In contrast, in HCV patients with no or only mild fibrosis (stage 1 or 2) and patients with prominent fibrosis or cirrhosis (stage 3 or 4) the frequency of the TT genotype was not significantly different (20/85 [23.5%]vs 9/36 [25.5%]).

Figure 2 Serum levels of sCD14 comparing TT-homozygote HCV patients and patients with genotypes CC or CT, respectively. Box plots illustrate median values and interquartile distance.