Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats

Figure 1 Colonic MPO activity in TNBS and control rats. ^bP < 0.01 vs controls distal colon.

Figure 2 NOS activity in different colon segments in TNBS and control rats. ^bP < 0.01 vs uninflamed mid-colon.

Figure 3 Frequency of phasic contractions of mid-colon circular muscle in controls compared to DUMC of TNBS rats. ^aP < 0.05 vs controls, ^bP < 0.01 vs controls.

Figure 4 Force of phasic contractions of mid-colon circular muscle in controls compared to DUMC of TNBS rats. ^bP < 0.01 vs controls.

Figure 5 High [K⁺]₀ induced contractile response of mid -colon circular muscle in controls compared to DUMC of TNBS rats. ^bP < 0.001 vs controls.

Figure 6 EFS evoked contraction of mid-colon circular muscle in controls compared to DUMC of TNBS rats. ^bP < 0.001 vs controls.

Figure 7 Pharmacological effects on EFS-evoked contractile responses recorded in the presence of L-NNA. ^bP < 0.001 vs controls.