Acute exacerbation of autoimmune hepatitis induced by Twinrix

Figure 1 Changes of alanine aminotransferase activity and serum bilirubin level on follow-up and during the therapy with budesonide and ursodeoxycholic acid.

Figure 2 A liver biopsy obtained 3 mo after the first clinical presentation of the patient showed marked bridging fibrosis (A). A moderate chronic inflammatory infiltrate with few scattered eosinophils was found in the septa (B), and an interface hepatitis was also noted (C). The histopathological findings were compatible with AIH. Masson trichrome stain (A) and H&E-stain (B and C). Original magnifications 100x (A and B) and 200x (C).