Effects of interferon-alpha on expression of hepatic stellate cell and transforming growth factor-β1 and α-smooth muscle actin in rats with hepatic fibrosis

Figure 1 Ultrastructure change, expression of TGF-β1 and α-SMA in model group and IFN-α preventing group respectively. A: Collagen fibers and activated HSC in Disse space in model group. EM×4000; B: The number of activated HSCs and apoptotic HSCs in IFN-α preventing group. EM×15000; C: TGF-β1 expression in portal area and fiber space in model group. SABC×100; D: Expression of TGF-β1 in hepatic tissue in IFN-α preventing group. SABC×100; E: α-SMA positive cells in portal area and fiber space in model group. SABC ×400; F: α-SMA positive cells in IFN-α preventing group. SABC×400.