Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh score and serum bile acid levels

Figure 1 Methacetin and phenylalanine breath tests: cumulative percent of oxidation at 60 and 120 min. A: Methacetin breath test: cumulative percent of oxidation at 60 and 120 min. CTR = controls; CH = chronic hepatitis; LCA = liver cirrhosis Child A; LCB = liver cirrhosis Child B; LCC = liver cirrhosis Child C. CTR vs CH, LCA, LCB, LCC: P<0.001 CH vs LCA, LCB, LCC: P<0.001 LCA vs LCB, LCC: P<0.001 LCB vs LCC: P<0.001. B: Phenylalanine breath test: cumulative percent oxidation at 60 and 120 min. CTR = controls; CH = chronic hepatitis; LCA = liver cirrhosis Child A; LCB = liver cirrhosis Child B; LCC = liver cirrhosis Child C. CTR vs LCB, LCC: P<0.001 CH vs LCB, LCC: P<0.001 LCA vs LCC: P<0.05.

Figure 2 Serum levels of cholic acid (CCA) and chenodeoxycholic acid (CDCA) conjugates. CTR = controls; CH = chronic hepatitis; LCA = liver cirrhosis Child A; LCB = liver cirrhosis Child B; LCC = liver cirrhosis Child C. aP<0.05 vs CH, LCA, LCB, LCC bP<0.001 vs LCA, LCB, LCC dP<0.001 vs LCB, LCC.

Figure 3 Area under the receiver operating characteristic (ROC) curves compared to the methacetin and phenylalanine breath tests between control subjects and liver disease patients as well as between chronic hepatitis and Child-Pugh A cirrhosis patients. A: Area under the receiver operating characteristic (ROC) curves compared to methacetin and phenylalanine breath tests between control subjects and liver disease patients. --M60 = cumulative percent oxidation of methacetin at 60 mins; -P60 = cumulative percent oxidation of phenylalanine at 60 min; B: Area under the receiver operating characteristic (ROC) curves compared to methacetin and phenylalanine breath tests between chronic hepatitis and Child-Pugh A liver cirrhosis patients. -M60 = cumulative percent oxidation of methacetin at 60 mins; --P60 = cumulative percent of oxidation of phenylalanine at 60 mins.