Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam

doi:10.3748/wjg.v10.i21.3165

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Nov 1, 2004 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 1, 2004; 10(21): 3165-3170
Published online Nov 1, 2004. doi: 10.3748/wjg.v10.i21.3165

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Figure 1 Intestinal lesions induced by meloxicam. A: Normal control rats; B: AA rats; C: AA rats given meloxicam intragastrically; D: AA rats treated with oral CII; E: AA rats treated with nasal CII; F: AA + meloxicam rats treated with oral CII; and G: AA + meloxicam rats treated with nasal CII.

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Figure 2 Effects of oral or nasal administration of CII on knee joint histopathology in AA rats with or without intragastrical administration of meloxicam (HE stain, × 100). A: Normal control rats (grade 0); B: AA rats (grade 4); C: AA rats given meloxicam intragastrically (grade 4); D: AA rats treated with oral CII (grade 3); E: AA rats treated with nasal CII (grade 2); F: AA + meloxicam rats treated with oral CII (grade 3); and G: AA + meloxicam rats treated with nasal CII (grade 2).

Citation: Zheng YQ, Wei W, Shen YX, Dai M, Liu LH. Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam. World J Gastroenterol 2004; 10(21): 3165-3170
URL: https://www.wjgnet.com/1007-9327/full/v10/i21/3165.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i21.3165