Copyright
©The Author(s) 2004.
World J Gastroenterol. Jan 15, 2004; 10(2): 161-166
Published online Jan 15, 2004. doi: 10.3748/wjg.v10.i2.161
Published online Jan 15, 2004. doi: 10.3748/wjg.v10.i2.161
Figure 1 Inhibition of staurosporine on MGC-803 cell proliferation.
Figure 2 Inhibition of staurosporine on SGC-7901 cell proliferation.
Figure 3 Morphological changes in MGC803 and SGC7901 cells under electron microscope after treatment with ST (200 ng/ml), ×5000.
A: MGC803 control cells, B: 200 ng/ml ST-induced MGC803 cells, C: SGC7901 control cells, D: 200 ng/ml ST-induced SGC7901 cells. Note: chromatin condensation and formation of apoptotic bodies.
Figure 4 Effect of ST on cell cycle of human gastric cancer cells.
A: Changes of cell cycle in MGC803 cells after ST-treatment for 24h, B: Changes of cell cycle in SGC7901 cells after ST-treatment for 24 h, C: ST-induced apoptosis in MGC-803 cells, D: ST-induced apoptosis in SGC-7901 cells.
Figure 5 Expression of P21 protein in MGC803 and SGC7901 cells after ST-treatment as determined by immunohistochemistry (SP×400).
A: MGC803 control cells, B: MGC803 cells treated with 60 ng/ml ST, C: SGC7901 control cells, D: SGC7901 cells treated with 60 ng/ml ST.
Figure 6 Effect of ST treatment on P21WAF1 mRNA expression in MGC803 cells.
M: DNA Marks, 1: control cells, 2: cells treated with 60 ng/ml ST.
Figure 7 Effect of ST treatment on P21WAF1 mRNA expression in SGC7901 cells.
M: DNA Marks, 1: control cells, 2: cells treated with 60 ng/ml ST.
- Citation: Ha MW, Hou KZ, Liu YP, Yuan Y. Effect of staurosporine on cycle human gastric cancer cell. World J Gastroenterol 2004; 10(2): 161-166
- URL: https://www.wjgnet.com/1007-9327/full/v10/i2/161.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i2.161