Function of oval cells in hepatocellular carcinoma in rats

Figure 1 Early inflammatory liver tissues in cancer inducing group at the 2nd wk and the differentiation of oval cells in the portal area (HE staining, original magnification: × 200).

Figure 2 A large quantity of oval cells gathered around the cancer nodes in cancer inducing group at 20th wk (HE staining, original magnification: × 200).

Figure 3 Electron microscopic observation showed: the volume of oval cell was about as big as one third of normal liver cell, round or oval shaped, scant cytoplasm with unclear cell margin.

Figure 4 Expression of c-kit in liver tissue in cancer inducing group at the 8th wk. The oval cells were mainly stained in portal areas (Immunohistochemistry, × 200).

Figure 5 Expression of c-kit in the HCC tissue in cancer inducing group in the 24th wk (Immunohistochemistry, × 200).

Figure 6 PCNA expression in HCC tissue in the cancer inducing group at the 24th wk (Immunohistochemistry, × 200).

Figure 7 Electrophoresis image of total RNA in rat liver tissue.

Figure 8 Products of RT-PCR of c-myc mRNA (up-strap: 228-bp c-myc; low-strap: 120-bp β-actin; Lanes1 and 2: Hepatocarcinoma tissue; Lane 3: Hepatocirrhosis tissue; Lanes 4-6: Inflammation tissue; Lane 7: Normal tissue).