Intestinal barrier damage caused by trauma and lipopolysaccharide

Figure 1 Alterations in architecture of small intestinal mucosa. (HE staining, original magnification: × 100). A: Normal mucous membrane of jejunum in control rats; B: Normal mucous membrane of ileum in control rats; C: Histological changes of jejunal mucosa of group T1 rats. The villi become sparser than those in control. The height and shape of villi are normal on the whole; D: Histological changes of ileal mucosa in PN group rats. The section shows a severe atrophy in mucosal structure. The villi become shorter, blunt and swollen; E: Histological changes of jejunal mucosa of Sep group. The villi are sparse and shorter than those of control group.

Figure 2 Morphometry for structure of small intestine mucosa (mean ± SE). ^bP < 0.001 vs EN, PN and Sep gorups; ^dP < 0.001 vs PN and Sep gorups; ^fP < 0.01 vs Sep gorup; ^hP < 0.005 vs PN and Sep gorups; ^jP < 0.001 vs Sep group; ^aP < 0.02 vs Sep gorup; ⁿP < 0.01 vs EN gorup; ^lP < 0.001 vs PN and Sep groups.