Transfection of IL-2 and/or IL-12 genes into spleen in treatment of rat liver cancer

Figure 1 CT scan of the liver cancer 7 d after implantation.

Figure 2 CT scan of the tumor treated with IL-2/IL-12 fused gene after 2 mo.

Figure 3 Pathological changes of implanted liver cancer (HE staining, original magnification: × 200). There are numerous lymphocytes in tumor tissues.

Figure 4 Activation of NK cell activity after administration of IL-2 and/or IL-12 (n = 5). ^bP < 0.01 vs control; ^aP < 0.05 vs IL-2 group or IL-12 group.