Effects of mifepristone on invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo

Figure 1 Effect of mifepristone on migration of MKN-45 cells incubated in Transwell cell culture chambers for 24 h in the absence (A) or presence of 10 μmol/L (B) and 20 μmol/L (C) mifepristone (H. E, ×200).

Figure 2 Metastatic foci in lungs of nude mice (arrow). After 24 h of fixation with Bouin’s solution, lung tissues exhibited yellow, whereas the tumors exhibited white.

Figure 3 Immunohistochemical detection of VEGF expression in xenografted gastric cancer tissues of nude mice treated for 8 wk without (A) or with (B) 50 mg/kg·d mifepristone (ABC, ×100).