Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma

Figure 1 Expressions of Stat3, p-Stat3, cyclin D1, and Bcl-x_L in colorectal carcinoma. Lysates were made as described under Materials and Methods. GAPDH represents the internal pro-tein control. Elevated levels of Stat3, p-Stat3 (Tyr-705), cyclin D1, and Bcl-x_L in tumor (T) tissues were compared to adjacent normal mucosae (N).

Figure 2 Expressions of Stat3, p-Stat3, cyclin D1, and Bcl-x_L in colorectal carcinoma. A: Cytoplasmic staining of Stat3 in CRC (original magnification × 200) ; B: Nuclear staining of p-Stat3 in CRC (original magnification × 200) ; C: Nuclear staining of cyclin D1 in CRC (original magnification × 200) ; D: Cytoplasmic staining of Bcl-x_L (original magnification × 200).