©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2015; 21(25): 7683-7708
Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7683
Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7683
Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis
Vasiliy Ivanovich Reshetnyak, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia
Author contributions: Reshetnyak VI solely contributed to this paper.
Conflict-of-interest statement: The author declare no conflict of interest.
Correspondence to: Vasiliy Ivanovich Reshetnyak, MD, PhD, DSc, Professor, Academic Secretary, V.A. Negovsky Research Institute of General Reanimatology, 25-2, Petrovka street, 107031 Moscow, Russian. vasiliy.reshetnyak@yandex.ru
Telephone: +7-495-6946505 Fax: +7-495-6946505
Received: February 4, 2015
Peer-review started: February 6, 2015
First decision: March 26, 2015
Revised: April 7, 2015
Accepted: June 10, 2015
Article in press: June 10, 2015
Published online: July 7, 2015
Peer-review started: February 6, 2015
First decision: March 26, 2015
Revised: April 7, 2015
Accepted: June 10, 2015
Article in press: June 10, 2015
Published online: July 7, 2015
Core Tip
Core tip: Primary biliary cirrhosis is a chronic autoimmune cholestatic liver disease. This review summarizes current literature data and our own experiences on clinical and laboratory criteria for the diagnosis of primary biliary cirrhosis. Thanks to advances in biochemistry, molecular biology and genetics, it became possible to present these data with regard to the pathophysiological mechanisms of their development.