Original Article
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World J Gastroenterol. Apr 28, 2013; 19(16): 2466-2472
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2466
Hepatocellular carcinoma in patients with chronic kidney disease
Chern-Horng Lee, Sen-Yung Hsieh, Ja-Liang Lin, Maw-Sen Liu, Tzung-Hai Yen
Chern-Horng Lee, Sen-Yung Hsieh, Ja-Liang Lin, Maw-Sen Liu, Tzung-Hai Yen, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Chern-Horng Lee, Maw-Sen Liu, Department of General Internal Medicine and Geriatrics, Chang Gung Memorial Hospital, Linkou 333, Taiwan
Sen-Yung Hsieh, Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Ja-Liang Lin, Tzung-Hai Yen, Department of Nephrology, Chang Gung Memorial Hospital, Taipei 105, Taiwan
Author contributions: Lee CH contributed to data analysis, write the paper and perform the study; Hsieh SY and Lin JL contributed to supervise the study; Lee CH, Hsieh SY, Lin JL, Liu MS and Yen TH contributed to patient care and management; Yen TH contributed to conceive and design the study, help in data analysis and manuscript writing.
Correspondence to: Tzung-Hai Yen, MD, PhD, Department of Nephrology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan. m19570@adm.cgmh.org.tw
Telephone: +886-3-3281200 Fax: +886-3-3282173
Received: October 12, 2012
Revised: January 16, 2013
Accepted: January 29, 2013
Published online: April 28, 2013
Processing time: 201 Days and 12 Hours
Core Tip

Core tip: There is a paucity of data regarding outcomes of hepatocellular carcinoma (HCC) in patients with chronic kidney disease (CKD), even though both hepatitis B virus and CKD are endemic in Taiwan. In a large-scale study, a total of 440 patients with HCC were categorized according to their CKD stage. At the end of analysis, it was found that HCC patients with stages 4 and 5 CKD suffered poorer survival than stages 1 and 2 CKD, which might be explained by inferior liver reserve. Interestingly, tumor stage was not a significant predictor for mortality according to a multivariate Cox regression model.