Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

doi:10.3748/wjg.v18.i22.2827

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Jun 14, 2012 (publication date) through Dec 17, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2012; 18(22): 2827-2831
Published online Jun 14, 2012. doi: 10.3748/wjg.v18.i22.2827

Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

Renata Hezova, Alena Kovarikova, Julie Bienertova-Vasku, Milana Sachlova, Martina Redova, Anna Vasku, Marek Svoboda, Lenka Radova, Igor Kiss, Rostislav Vyzula, Ondrej Slaby

Renata Hezova, Alena Kovarikova, Milana Sachlova, Martina Redova, Marek Svoboda, Igor Kiss, Rostislav Vyzula, Ondrej Slaby, Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech

Julie Bienertova-Vasku, Anna Vasku, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech

Martina Redova, Ondrej Slaby, Central European Institute of Technology, Masaryk University, 625 00 Brno, Czech

Lenka Radova, Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and Palacky University Affiliated Hospital Olomouc, 775 15 Olomouc, Czech

Author contributions: Hezova R and Kovarikova A performed DNA purifications and single nucleotide polymorphism analysis; Sachlova M, Vasku A, Svoboda M, Kiss I and Vyzula R collected DNA samples and clinical data from patients and controls involved in the study; Radova L performed statistical evaluation of the collected data; Bienertova-Vasku J, Redova M and Slaby O participated in manuscript preparation; and Slaby O designed the study, performed the data analysis and interpretation, and critically revised the manuscript.

Supported by Czech Ministry of Health, No. NS 10352-3/2009, NS/9814 and project No. MZ0MOU2005; the Ministry of Education, Youth and Sports for the project BBMRI CZ, No. LM2010004; and the project ‘‘CEITEC-Central European Institute of Technology’’, No. CZ.1.05/1.1.00/02.0068

Correspondence to: Ondrej Slaby, PhD, Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech. slaby@mou.cz

Telephone: +420-5-43136902 Fax: +420-5-43136902

Received: August 13, 2011
Revised: September 24, 2011
Accepted: April 12, 2012
Published online: June 14, 2012

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