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World J Gastroenterol. Jan 14, 2010; 16(2): 201-209
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.201
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.201
Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection
Xiao-Nan Zhang, Zhi-Gang Song, Ting Jiang, Yun-Wen Hu, Zheng-Hong Yuan, Research Unit, Shanghai Public Health Clinical Center, Caolang Road 2901, Shanghai 201508, China
Bi-Sheng Shi, Zheng-Hong Yuan, Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University Dongan Road 130, Shanghai 200032, China
Author contributions: Zhang XN performed the majority of experiments and molecular simulations; Song ZG provided cDNA samples of EV71 infected patients; Jiang T performed phylogenetic analyses; Shi BS performed the cloning and sequencing of EV71 3C protease fragments; Hu YW and Yuan ZH coordinated and helped design the project.
Supported by Start-up Fund (No. KSF0062) of the Shanghai Public Health Clinical Center
Correspondence to: Zheng-Hong Yuan, Professor, Research Unit, Shanghai Public Health Clinical Center, Caolang Road 2901, Shanghai 201508, China. zhyuan@shaphc.org
Telephone: +86-21-64161928 Fax: +86-21-64227201
Received: October 7, 2009
Revised: November 8, 2009
Accepted: November 15, 2009
Published online: January 14, 2010
Revised: November 8, 2009
Accepted: November 15, 2009
Published online: January 14, 2010
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