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©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Dec 21, 2009; 15(47): 5924-5935
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5924
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5924
TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies
Bruno Christian Koehler, Toni Urbanik, Binje Vick, Regina Johanna Boger, Peter R Galle, Marcus Schuchmann, Henning Schulze-Bergkamen, First Department of Medicine, Johannes Gutenberg-University Mainz, 55101 Mainz, Germany
Steffen Heeger, Merck KGaA, MS-D Global Clinical Development Unit - Oncology, 64293 Darmstadt, Germany
Henning Schulze-Bergkamen, National Center of Tumor Diseases, Department of Medical Oncology, University Clinic of Heidelberg, 69120 Heidelberg, Germany
Author contributions: Koehler BC and Urbanik T performed the experiments and substantially contributed equally to the conception and design of the study, interpretation of the data and statistical analysis; Koehler BC, Urbanik T and Schulze-Bergkamen H wrote the manuscript; Vick B, Boger RJ, Schuchmann M, Schulze-Bergkamen H and Galle PR made substantial contribution to the design and conception of the study and interpretation of data; all authors read and approved the final manuscript; this study contains essential parts of the medical thesis work of Koehler BC.
Supported by Research grants from Merck KGaA, Darmstadt, Germany, to Schulze-Bergkamen H
Correspondence to: Henning Schulze-Bergkamen, MD, PhD, National Center of Tumor Diseases, Department of Medical Oncology, University Clinic of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany. henning.schulze@med.uni-heidelberg.de
Telephone: +49-6221-560 Fax: +49-6221-568815
Received: September 25, 2009
Revised: November 12, 2009
Accepted: November 19, 2009
Published online: December 21, 2009
Revised: November 12, 2009
Accepted: November 19, 2009
Published online: December 21, 2009
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