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©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Mar 28, 2009; 15(12): 1431-1442
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1431
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1431
Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration
Julia Brenmoehl, Sandra Nicole Miller, Claudia Hofmann, Daniela Vogl, Werner Falk, Jürgen Schölmerich, Gerhard Rogler, Department of Internal Medicine I, University of Regensburg, 93055 Regensburg, Germany
Julia Brenmoehl, Department of Internal Medicine II, University of Jena, 07747 Jena, Germany
Gerhard Rogler, Clinic of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Zurich, 8091 Zurich, Switzerland
Author contributions: Brenmoehl J performed the quantitative mRNA analyses (Taqman-PCR) and western blotting of fibronectin and the fibronectin isoforms, and wrote the manuscript; Miller SN performed the migration assays, western blotting and staining of a-smooth muscle actin, and wrote the manuscript; Hofmann C performed the western blotting of phosphorylated and total focal adhesion kinase and wrote the manuscript; Vogl D contributed to biopsies collection, data collection and isolation of colonic lamina propria fibroblasts; Falk W contributed to data interpretation and to writing the manuscript; Schölmerich J contributed to the overall interpretation of data and writing of the manuscript; Rogler G planned and co-ordinated the study and wrote the manuscript.
Correspondence to: Julia Brenmoehl, PhD, Department of Internal Medicine II, University of Jena, Jena 07747, Germany. julia.brenmoehl@med.uni-jena.de
Telephone: +49-3641-9324227
Fax: +49-3641-9325827
Received: May 24, 2008
Revised: October 15, 2008
Accepted: October 22, 2008
Published online: March 28, 2009
Revised: October 15, 2008
Accepted: October 22, 2008
Published online: March 28, 2009
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