Bcl-xL and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells

doi:10.3748/wjg.14.3829

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Jun 28, 2008 (publication date) through Nov 9, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Jun 28, 2008; 14(24): 3829-3840
Published online Jun 28, 2008. doi: 10.3748/wjg.14.3829

Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells

Henning Schulze-Bergkamen, Roland Ehrenberg, Lothar Hickmann, Binje Vick, Toni Urbanik, Christoph C Schimanski, Martin R Berger, Arno Schad, Achim Weber, Steffen Heeger, Peter R Galle, Markus Moehler

Henning Schulze-Bergkamen, Roland Ehrenberg, Lothar Hickmann, Binje Vick, Toni Urbanik, Christoph C Schimanski, Peter R Galle, Markus Moehler, First Department of Medicine, Johannes-Gutenberg-University Mainz, Mainz 55101, Germany

Martin R Berger, German Cancer Research Center, Heidelberg 69120, Germany

Arno Schad, Institute of Pathology, University of Mainz, Mainz 55101, Germany

Achim Weber, Department of Pathology, Institute of Surgical Pathology, University Hospital, Zürich 8091, Switzerland

Steffen Heeger, Merck Pharma GmbH, Darmstadt 64293, Germany

Author contributions: Schulze-Bergkamen H, Ehrenberg R contributed equally to this work; Schulze-Bergkamen H, Ehrenberg R, Hickmann L, Urbanik T and Vick B performed the experiments of the study and made substantial contributions to conception and design of the study, interpretation of the data and statistical analysis; Schulze-Bergkamen H drafted the manuscript; Moehler M, Heeger S and Galle PR made substantial contributions to conception, design and interpretation of data; Schimanski CC and Berger MR participated in the design of the study and in the analysis of colorectal carcinoma tissue samples; Schad A and Weber A performed the immunhistochemical analysis of colorectal carcinoma tissues; all authors read and approved the final manuscript; this study contains essential parts of the medical thesis work of Ehrenberg R and Hickmann L.

Correspondence to: Henning Schulze-Bergkamen, MD, PhD, First Department of Medicine, Johannes-Gutenberg-University Mainz, Langenbeckstrasse 1, Mainz 55101, Germany. bergkam@uni-mainz.de

Telephone: +49-6131-172462

Fax: +49-6131-175529

Received: March 4, 2008
Revised: May 8, 2008
Accepted: May 15, 2008
Published online: June 28, 2008

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