Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL. ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. World J Gastroenterol 2026; 32(5): 115301 [PMID: 41693979 DOI: 10.3748/wjg.v32.i5.115301]
Andrzej S Tarnawski, MD, PhD, Professor
May 13, 2026, 08:23
Title: ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SICAM2/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. The authors' study highlighted the clinical impact of ICAM2 downregulation that predict poor outcome and neoadjuvant response in advanced gastric cancer (AGC) patients, and demonstrated a novel ICAM2/TGF-β/Smad/SP1/PTN signaling mediating 5-FU resistance in AGC. Clinically important article.
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