Title: Mechanism of anti-HuD autoantibody inducing enteric neuronal apoptosis of irritable bowel syndrome and its potential for targeted intervention. In this experimental study, the authors developed an antibody-mediated IBS model and demonstrated that anti-HuD autoantibodies directly induced apoptosis in enteric neurons by disrupting HuD-mediated RNA regulation. HuD autoantibodies reduced the stability of downstream mRNA and suppressed phosphatidylinositol 3-kinase-protein kinase B signaling, leading to neuronal loss and IBS-like gastrointestinal dysfunction. Moreover, they showed that pharmacological activation of protein kinase C restored HuD expression and alleviated neuronal apoptosis. This study highlights a potential therapeutic strategy for IBS associated with autoimmune-mediated enteric neuropathy. The authors should clearly state in the title and abstract what HuD is - stands for.