Title: Baseline multimodal clinical-radiomics-pathomics model predicts mucosal healing in Crohn's disease after infliximab therapy. The authors introduced a novel model that combines clinical, radiomics, and pathomics data to predict mucosal healing (MH) in patients with Crohn's disease (CD) following infliximab (IFX) therapy. This study integrates macro-level imaging (spectral CTE) with micro-level histopathology (pathomics) to predict mucosal healing (MH). Notably, it employs a site-specific approach, developing separate predictive models for ileal and ileocolonic Crohn's disease (CD), thereby enabling investigation of regional differences in pathological mechanisms and treatment responses. This strategy demonstrates strong potential for clinical application.