BPG is committed to discovery and dissemination of knowledge
Articles Published Processes Featured Articles Journals Submit a Manuscript
Citation
Wang XP, Liu C, Zhang HW, Zhai JM, Zhu JX, Sun GD, An YH, Yang HJ, Jing DS, Liu DC. H3K18 La-METTL5-CCT2 signaling axis promotes colorectal cancer progression by inhibiting pyroptosis. World J Gastroenterol 2026; 32(31): 118472 [DOI: 10.3748/wjg.118472]
Full Article (HTML) Full Article (PDF)
(29) (32) (0) (1) (8) (391)
Comments (1)
Andrzej S Tarnawski, MD, PhD, Professor August 24, 2026, 09:21
This study systematically elucidates the molecular mechanism by which the H3K18la METTL5–CCT2 signaling axis promotes colorectal cancer (CRC) progression by inhibiting pyroptosis. It also validated the potential of the PI3Kβ inhibitor AZD6482 to improve chemotherapy sensitivity in a high-lactate microenvironment. This study offered a novel perspective on metabolic-epigenetic regulation and the potential for targeted therapy in CRC.
(0) (0) (0)
Please LOGIN to submit a new comment.
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.