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Wang SF, Guo HC, Peng XW. Beyond adenomatous polyposis coli: Redefining the genetic architecture of familial adenomatous polyposis through recurrent variants of uncertain significance. World J Gastroenterol 2026; 32(32): 117091 [DOI: 10.3748/wjg.117091]
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Andrzej S Tarnawski, MD, PhD, Professor August 31, 2026, 00:33
This editorial offers a highly original interpretation of Tóth et al., introducing the innovative “genomic ecosystem” framework and proposing a substantial revision of both the genetic architecture and clinical-management paradigm of familial adenomatous polyposis (FAP). An important new mechanism.
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