Title: Ethnic divergence in human leukocyte antigen-linked immunogenicity in inflammatory bowel disease: lessons from Taiwan. This editorial provides insightful commentary on the study by Wen et al., which investigates the HLA-associated immunogenicity of biologic therapies in Taiwanese patients with inflammatory bowel disease (IBD). It highlights ethnic-specific differences in genetic risk factors for anti-drug antibody (ADA) formation, challenging the presumed universality of HLA-DQA105, which has been identified as a major risk allele in European cohorts, while introducing novel susceptibility alleles, including HLA-C03:04:01 and HLA-B*15:18:01. The article underscores the importance of developing ethnicity-tailored approaches to predicting and managing immunogenicity.