Yu QT, Lin YY, Gui ZH, Duan HL, Yang JJ, Meng Y, Peng XT, Liu L, Wan H, Shen J. Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(21): 118057 [DOI: 10.3748/wjg.v32.i21.118057]
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03664074
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May 28, 2026, 07:30
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Reader Comments:
This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients using reduced odds ratio which can display the critical role of sleep management. There is a phenomenon hardly to understand where the improper cases is excluded in specific step with corresponding numbers in the flowchart of figure 1.
Reader's ID:
03769692
Submitted on:
May 26, 2026, 15:36
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Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
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11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
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Reader Comments:
The article focuses on the relationship between the Healthy Sleep Score and MASLD. The significance of this study lies in suggesting that overall sleep health may be an important and relatively modifiable factor in the prevention and management of MASLD. For clinical and health management readers in particular, the study emphasizes not just a single sleep problem, but the combined effects of multiple dimensions of sleep, including sleep duration, sleep rhythm, insomnia, sleep apnea, and daytime sleepiness. This provides valuable insights for the early screening, lifestyle intervention, and risk stratification of MASLD. In addition, the authors propose that insulin resistance and inflammation may partially mediate the relationship between sleep and MASLD, offering directions for future mechanistic research and integrated intervention strategies. Although the study is cross-sectional in design and therefore cannot directly establish causality, its relatively large community-based sample and comprehensive analytical framework still make it a useful reference for understanding the link between sleep and metabolic liver disease.