Lin C, Fu RK, Zheng H, Li TY, Han JS, Margonis GA, Wang JJ, Dong LB, Wang NS, Sun YX, Wang YZ, Liu C, Xu Q, Han XL, Zhang TP, Guo JC, Dai MH, Xia P, Chen LM, Wang WB. Development and validation of an interpretable machine learning model for predicting acute kidney injury after pancreatic surgery. World J Gastroenterol 2026; 32(19): 116271 [DOI: 10.3748/wjg.v32.i19.116271]
Reader's ID:
07868007
Submitted on:
May 22, 2026, 01:57
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
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Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
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9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
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11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
This study focuses on postoperative acute kidney injury (AKI), one of the most challenging complications in the field of pancreatic surgery. It adopts advanced machine learning methods to construct the first interpretable predictive model specifically tailored for patients undergoing pancreatic surgery and develops an online risk calculator. Overall, this is a high-quality study with rigorous design, advanced methodology and clear clinical orientation, which has made significant contributions to the development of this field. However, it also has several issues worthy of in-depth discussion:
a. The single-center retrospective design limits the generalizability of the results;
b. There is a lack of independent external validation;
c. The model incorporates 24-hour postoperative data, which restricts its application in preoperative risk assessment;
d. It fails to distinguish between AKI subtypes with different etiologies and severity grades.
Despite these limitations, this study has laid a solid foundation for research on the prediction of AKI after pancreatic surgery and also provides a valuable reference for predictive studies of other surgical complications.
Reader's ID:
03664074
Submitted on:
May 19, 2026, 07:17
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
This retrospective study displayed a critical role in the performing of training and testing results using several artificial techniques in the occurrence of acute kidney damage clinically. Although it is meaningful to indicate the incidence of acute kidney injury after clinical treatment, there are several issues to need further explanation for achieving better effect by readers such that the patient number difference between training and testing group presented significantly as well as the cross sections among acute kidney injury or non-acute kidney injury versus training cohort and validation cohort displayed without overlapped demonstration.