Jiang H, Yan JH, Tang WJ, Shen B, Mo S, Wang Y, Hu DH, Dong ZX, Zhang SB. PRMT5 imposed a dual repression on DDIT3 transcription to promote the malignancy of hepatocellular carcinoma. World J Gastroenterol 2026; 32(19): 115332 [DOI: 10.3748/wjg.v32.i19.115332]
Reader's ID:
08628847
Submitted on:
May 19, 2026, 15:31
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Reader Comments:
The article indicates that high PRMT5 expression is associated with poor prognosis in hepatocellular carcinoma (HCC). It further reveals that PRMT5 can suppress DDIT3 transcription by enhancing H4R3me2 modification at the DDIT3 promoter region and recruiting STAT3, thereby promoting anti-apoptotic behavior and malignant progression of tumor cells. This mechanism links epigenetic regulation, transcription factor cooperation, and tumor cell escape from apoptosis, providing a new perspective for understanding the development and progression of HCC. A key strength of the article is that it not only identifies the association between PRMT5 and prognosis, but also further elucidates the dual inhibitory mechanism by which PRMT5 regulates DDIT3, making the study’s conclusions more biologically convincing.