Darnindro N, Abdullah M, Sukartini N, Rumende CM, Pitarini A, Nursyirwan SA, Fauzi A, Makmun D, Nelwan EJ, Shatri H, Rinaldi I, Tanadi C. Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia. World J Gastroenterol 2025; 31(7): 100051 [PMID: 39991683 DOI: 10.3748/wjg.v31.i7.100051]
Reader's ID:
08398088
Submitted on:
January 21, 2025, 22:39
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Reader Comments:
As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors effectively highlight differences in mucosa-associated colonic microbiota between colorectal cancer (CRC) and non-CRC patients in Indonesia.
A key strength is the focus on mucosal rather than fecal microbiota, providing a clearer picture of the tumor microenvironment. The use of 16S rRNA sequencing with Oxford Nanopore Technologies enables detailed bacterial diversity analysis at the genus and species levels.
The study confirms the increased presence of Fusobacterium nucleatum and Bacteroides fragilis in CRC patients, supporting the link between microbial dysbiosis and carcinogenesis. The diagnostic potential of these bacterial markers is particularly noteworthy.
Further research with larger sample sizes and functional analyses, such as metagenomics or metabolomics, would enhance understanding of microbiota’s role in CRC. Additionally, while this study offers important insights for Asia, global research is needed to assess regional differences and their impact on CRC diagnostics and treatment.
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