Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF. Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study. World J Gastroenterol 2025; 31(38): 109528 [PMID: 41112004 DOI: 10.3748/wjg.v31.i38.109528]
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October 15, 2025, 21:18
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Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for oligometastatic colorectal cancer (CRC) with lung involvement. Among 336 patients treated between 2014 and 2022, the 3- and 5-year overall survival rates were 59.5% and 41.0%, respectively, demonstrating meaningful long-term benefit. Extrapulmonary metastases, particularly in the bone and abdominal cavity, significantly worsened outcomes, whereas patients with liver-only metastases had comparatively favorable survival. Elevated tumor markers (CEA, CA19-9), greater tumor burden, and absence of systemic therapy were adverse prognostic factors. Notably, combining IGTA with systemic therapy improved overall survival. This study underscores IGTA as a viable, minimally invasive treatment for patients with oligometastatic CRC and highlights the prognostic relevance of metastatic distribution in guiding personalized therapy.
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October 14, 2025, 15:07
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This manuscript is well-written and well-prepared.
The previous history of adjuvant chemotherapy might have an impact on the oligometastatic disease, particularly in colorectal cancer patients.For the long-term follow-up, this current modality of treatment should be considered as one of the options in giving the multimodality treatment in this case.
The methods is already clear.
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03664074
Submitted on:
October 14, 2025, 14:51
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6 Results
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Reader Comments:
This study explored that the method of thermal therapy displayed a beneficial role in the prognosis of oligometastatic colorectal lung metastases in patients. It should present the histology features including clinical tumor formation and CT images especially in the determination of different tumor size and outcomes under patients after treatment as author mentioned in this study. In addition, the numbers of distinct groups used for comparison performed a large difference in the statistical analysis.