Vargas-Beltran AM, Armendariz-Pineda SM, Martínez-Sánchez FD, Martinez-Perez C, Torre A, Cordova-Gallardo J. Interplay between endocrine disorders and liver dysfunction: Mechanisms of damage and therapeutic approaches. World J Gastroenterol 2025; 31(32): 108827 [PMID: 40900772 DOI: 10.3748/wjg.v31.i32.108827]
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03769692
Submitted on:
September 06, 2025, 07:30
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Reader Comments:
The article provides a comprehensive review of the interplay between endocrine disorders and liver dysfunction, offering insightful perspectives on how various hormonal imbalances contribute to liver diseases such as metabolic liver disease and cirrhosis. From a clinical standpoint, the paper emphasizes the bidirectional nature of this relationship, with endocrine dysfunction not only exacerbating liver conditions but also liver damage impacting hormone metabolism. The article goes beyond theoretical mechanisms, proposing multidisciplinary management strategies that could improve patient outcomes, especially in conditions like non-alcoholic fatty liver disease (NAFLD) and cirrhosis. The therapeutic approaches outlined, including the integration of endocrine evaluation in liver disease care, underline the importance of a holistic treatment model for more personalized and effective interventions. Overall, this review is an essential resource for researchers and clinicians aiming to refine treatment protocols for patients with complex liver-endocrine disorders, providing a deeper understanding of the underlying pathophysiology and offering practical recommendations for integrated care.
Reply from the Editorial Office:
Thank you very much for your comments.
Reader's ID:
05533197
Submitted on:
September 02, 2025, 09:50
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
This review takes the bidirectional relationship between the endocrine system and liver function as its starting point and systematically outlines the roles of the thyroid, parathyroid, pancreas, adrenal glands, and sex hormones in liver diseases. It not only summarizes the interactions between common endocrine disorders (such as hypothyroidism, insulin resistance, and Cushing’s syndrome) and hepatic injury, but also provides mechanistic insights into key processes, including lipid metabolism disorders, oxidative stress, and hormone conversion. In addition, the article discusses emerging therapeutic approaches, highlighting the potential of TRβ agonists, GLP-1 receptor agonists, and SGLT2 inhibitors. By emphasizing the mutual reinforcement between endocrine disorders and liver diseases, this review offers valuable references for clinicians in the management of MASLD/NASH, cirrhosis, and hormone-related conditions. Importantly, it reminds us that future strategies for liver disease treatment should not be confined to the liver itself, but must also integrate the broader endocrine context.
Nevertheless, the review also has certain limitations. Some sections remain primarily descriptive and observational, with relatively limited exploration of molecular pathways and immune-metabolic interactions. Furthermore, the discussion of sex hormones and the parathyroid axis is relatively brief and lacks incorporation of the latest clinical evidence. Looking ahead, integration of multi-omics technologies with large-scale clinical datasets will be essential to further advance knowledge in this field and to promote the development of interdisciplinary diagnostic and therapeutic strategies.
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