Pan SD, Xiong CY, Shen YJ, Tian JH, Wang YL, Wang JN, Wang SY, Li FY, Wang LF, Qiu Q, Yang L, Liu XM, Luan JQ, Zou ZS, Wang FS, Meng FP. MicroRNA-126-3p as a predictive biomarker for patients with primary biliary cholangitis refractory to ursodeoxycholic acid. World J Gastroenterol 2025; 31(31): 109828 [PMID: 40901689 DOI: 10.3748/wjg.v31.i31.109828]
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03769692
Submitted on:
August 21, 2025, 17:07
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Reader Comments:
This paper presents an insightful exploration into the potential of miR-126-3p as a predictive biomarker for treatment response in patients with primary biliary cholangitis (PBC) who are refractory to ursodeoxycholic acid (UDCA). The study highlights the variability in therapeutic responses among PBC patients and proposes miR-126-3p as a reliable marker for distinguishing between UDCA-sensitive and resistant individuals. This could be a game-changer in personalized medicine, allowing for more tailored and effective treatment strategies. The use of a cohort-based approach with rigorous statistical analysis, including ROC curve evaluation, enhances the credibility of the findings. From a clinical perspective, the identification of miR-126-3p as a biomarker with high sensitivity and specificity (82.4% sensitivity and 84.6% specificity) for predicting UDCA responsiveness is highly promising. It could facilitate earlier interventions for non-responders, preventing the progression of the disease and reducing the need for liver transplantation. The findings of this study are particularly important in clinical settings where timely adjustments in treatment are critical for improving patient outcomes.
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