Yang QH, Zhang CN. Comparative study on the pathogenesis of Crohn’s disease and ulcerative colitis. World J Gastroenterol 2025; 31(19): 106406 [PMID: 40497094 DOI: 10.3748/wjg.v31.i19.106406]
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Submitted on:
May 27, 2025, 06:45
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Reader Comments:
This paper systematically analyzes the etiology of the two major subtypes of inflammatory bowel disease (IBD): Crohn’s disease and ulcerative colitis. It is highly comprehensive and commendable. It examines the etiology broadly, focusing on immune responses and considering genetic changes, gut microbiota, and social and environmental factors. On the other hand, further discussion is needed regarding how concretely these theoretical insights into etiology are linked to the development of therapeutic approaches. Additionally, genetic factors and changes in gut microbiota can vary by region, making universal evaluation difficult.
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Reader's ID:
03769692
Submitted on:
May 25, 2025, 08:22
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Reader Comments:
This minireview article provides a systematic comparison of the pathogenic mechanisms of Crohn’s disease and ulcerative colitis. It outlines six shared mechanisms—including immune dysregulation, genetics, microbiota imbalance, and infections—and identifies 14 key differences between the two diseases. The article is well-structured, comprehensive in scope, and supported by clear diagrams, offering strong academic value and clinical relevance. While its originality and depth of mechanistic insight could be further improved and the discussion on clinical translation is somewhat limited, it remains a well-organized and information-rich review suitable for researchers and clinicians alike.
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Reader's ID:
03721258
Submitted on:
May 21, 2025, 12:34
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Reader Comment Standards for Published Articles:
1 Title
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2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
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4 Background
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5 Methods
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6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
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Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
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11 References
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13 Ethics statements
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Reader Comments:
Six common and fourteen unique aspects of the pathogenesis of inflammatory bowel disease, primarily Crohn’s disease and ulcerative colitis, illustrate the causes and beneficial factors of resistance to inflammatory bowel disease, providing critical insights for the targeted treatment of Crohn’s disease and ulcerative colitis. Utilizing the main contents of this paper allows for the development of comprehensive interventions that reduce harmful influences, enhance protective factors and use an integrative approach to address the diseases for the benefit of the human being
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