Seddik H, Benass J, Berrag S, Sair A, Berraida R, Boutallaka H. Optimized sequential therapy vs 10- and 14-d concomitant therapy for eradicating Helicobacter pylori: A randomized clinical trial. World J Gastroenterol 2024; 30(6): 556-564 [PMID: 38463026 DOI: 10.3748/wjg.v30.i6.556]
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05194776
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February 25, 2024, 15:29
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Reader Comments:
It is well known that H. pylori infection is a common infection worldwide and the treatment of H. pylori remains a global concern due to the prevalence of antimicrobial resistance. This study was a single-center, prospective, open-label, randomized study comparing the efficacy of optimized sequential therapy for 14 days with that of combination therapy for 10 days and 14 days. Data analysis showed that the use of optimized sequential therapy improved the eradication rate of H. pylori infection and reduced the incidence of adverse reactions. This provides us clinicians with more radical treatment options for H. pylori infection. It is expected that this study can be further verified in multi-center and multi-region studies.
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Submitted on:
February 23, 2024, 02:24
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Reader Comments:
The study and its results are valuable and can be readily applied in clinical practice, however the use of a different PPI solely on the sequential therapy group makes it difficult to assess if the difference in edificacy/cost is due to concomitant vs sequential or Omeprazole vs Rabeprazole
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Reader's ID:
04031698
Submitted on:
February 20, 2024, 08:52
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Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
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10 Units
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11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
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Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
Worth in-depth learning
Reply from the Editorial Office:
Thank you very much for your comments.