Triantafillidis JK, Zografos CG, Konstadoulakis MM, Papalois AE. Combination treatment of inflammatory bowel disease: Present status and future perspectives. World J Gastroenterol 2024; 30(15): 2068-2080 [PMID: 38681984 DOI: 10.3748/wjg.v30.i15.2068]
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April 29, 2024, 13:25
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Reader Comments:
Hepatocellular carcinoma patients with cirrhosis have a poor prognosis and a high recurrence rate after hepatectomy. Therefore, it is important to construct a predictive model to predict ER in such patients. In this paper, five different machine learning algorithms were used to compare the performance of three different models of clinical radiology, radiomics and combinatorics, and finally a combined model under the KNN algorithm was constructed to predict ER of such patients and stratify the overall survival (OS) of patients. This means that individual therapies can be targeted to patients with hepatocellular carcinoma in the context of cirrhosis.
The advantage of this paper is to compare the AUC values of different models under a variety of different machine learning algorithms, so as to select the model with the most predictive power to predict early relapse in patients. The disadvantage is that the included sample size is small, which limits the accuracy of machine learning.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.
Reader's ID:
03475595
Submitted on:
April 25, 2024, 14:00
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
The manuscript is well-written and provides a thorough overview of a complex and important topic in gastroenterology. The topic of combination treatment for inflammatory bowel disease (IBD) is highly relevant given the complexity of managing IBD, especially in cases of severe or refractory disease. The manuscript addresses a significant clinical challenge and offers insights into current and future treatment strategies, which is important for the gastroenterology community. The authors offer a balanced view by discussing both the potential benefits and the risks associated with combination treatments. The objectives are clearly stated, focusing on the present status and future perspectives of combination treatments for IBD. The authors summarize existing data by searching on electronic databases such as PubMed, Medline, and Cochrane CENTRAL, which is a standard approach, and on combination therapies and propose thoughts for future applications, including the potential use of biomarkers and artificial intelligence. The presentation is structured, with tables summarizing the results of clinical trials, which aids in the readability and understanding of the findings. This manuscript contributes valuable insights into the treatment of IBD and would be of interest to clinicians and researchers in the field.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.