Ishida N, Ito T, Takahashi K, Asai Y, Miyazu T, Higuchi T, Tamura S, Tani S, Yamade M, Iwaizumi M, Hamaya Y, Osawa S, Sugimoto K. Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission. World J Gastroenterol 2023; 29(47): 6111-6121 [PMID: 38186681 DOI: 10.3748/wjg.v29.i47.6111]
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03266250
Submitted on:
January 06, 2024, 14:08
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Reader Comments:
The comparison of biomarkers and various endoscopic scores as predictors of illness recurrence is the study's highlight. According to the AGA 2023 guideline, blood C-reactive protein (CRP), fecal calreticulin, and fecal lactoferrin, as well as clinical presentation, are established indicators of disease activity in patients with UC. Symptoms in remission or with active symptoms. In addition, a lot of studies show that FC can predict UC. This is intriguing since biomarkers can lessen the discomfort of patients. Despite the fact that the final data showed that UCEIS was the strongest predictor of UC recurrence, as expected, Furthermore, this study found that FC = 323 mg/kg was the best predictor of UC recurrence; does this result still need to be paired with the UCCIS or UCEIS score? In what instances, for example, may this be assessed without integrating the endoscopic score? Is it possible to answer whether UC recurrence may be predicted independently using FC? Can it be utilized with 76% precision? How long does predicting recurrence take? A more precise range? A combination of clinical symptoms, biomarkers, and so forth. It would be more rigorous if validated results were available. If these questions cannot be answered, we will need to conduct more biomarker investigations and validation at a later date.
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First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
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Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.
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January 01, 2024, 13:05
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Reader Comments:
The article is quite interesting in terms of its objectives and conclusions. The latter are based on good statistics. I have doubts about both the cutoff point of fecal calprotectin and its timing of collection, especially when it has been collected after colonoscopy. At certain points, the expressions could be improved to facilitate reading, but overall, it is readable. I agree with the authors that new studies are needed to find alternatives to FC that are more reliable for evaluating these patients.
Congratulations on your article.
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Thank you very much for your comments.
Reader's ID:
06642109
Submitted on:
January 01, 2024, 02:50
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2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
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Reader Comments:
Very informative manuscript on a highly relevant topic. Well explained and placed in the context of current literature. Figures were well constructed and thoughtfully detailed. There were occasionally some grammatical errors and particularly long sentences which impeded the coherence of certain paragraphs, however, this paper was otherwise well written.
As a minor side note, I question the accuracy associated with measuring FC after colonoscopy. There is some evidence to suggest that the timing of collection after colonoscopy may influence FC values. To a much lesser extent, bowel preparation itself may lower the FC value. Future work could potentially look into controlling the timing of collection to either pre or post colonoscopy, as opposed to pooling the data.
Congratulations on a job well done.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.