Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M. Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology. World J Gastroenterol 2023; 29(38): 5361-5373 [PMID: 37900587 DOI: 10.3748/wjg.v29.i38.5361]
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Reader Comments:
Dear authors,
We would like to express our heartfelt gratitude to Dan Xu and his team for choosing to publish their latest research in the World Journal of Gastroenterology. Their outstanding article aims to illuminate the expression characteristics and significance of the cck-A receptor in CBD ICLC, as well as the role of CCK in regulating CBD movement through specific receptors. This topic is truly captivating. Through their meticulous experiments, they have demonstrated that CCK causes dose-dependent contractions of smooth muscle within a specific concentration range, and that it can also regulate CBD contractions by binding with the CCK-A receptor on ICLC. These findings will offer fresh insights into the study of biliary autonomic movement and the treatment of biliary diseases. We are delighted to read such an intriguing article. We eagerly anticipate the submission of similar high-quality articles from your research team in the future.
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First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
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Reader Comments:
It is an interesting and explanatory work.
The description of the immunostaining panel should be expanded to distinguish the different differentiations of the lesions; since this parameter is of vital importance for the conclusions of the work and for the classification of the tumors described
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Thank you very much for your comments.
Reader's ID:
00058511
Submitted on:
October 18, 2023, 05:07
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Reader Comment Standards for Published Articles:
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2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
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4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
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Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
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Reader Comments:
I read with great interest this paper by Mocchegiani et al and I would like to congratulate the authors for their very nice work on the intraductal papillary neoplasm of the bile duct (IPNB), which is an updated impressive approach. This neoplasm resembles the pancreatic intraductal papillary mucinous neoplasm (IPMN), which was first described by Ohashi in 1982 and is considered a premalignant lesion of pancreatic ductal adenocarcinoma. However, the IPNB is rare, less common than IPMN, and more aggressive lesion, since it is more transformed into cholangiocarcinoma. IPNB is manifested by obstructive jaundice and episodes of acute cholangitis and must be kept in mind, when someone is faced with such a clinical setting, but without common bile duct gallstones. Thus, it is important the early diagnosis and proper management of this precancerous lesion to prevent a dismal course improving the long-term oncological outcome.
Theodoros E Pavlidis
Emeritus Professor
School of Medicine, Aristotle University of Thessaloniki, Greece
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.