Zhu K, Kakkar R, Chahal D, Yoshida EM, Hussaini T. Efficacy and safety of semaglutide in non-alcoholic fatty liver disease. World J Gastroenterol 2023; 29(37): 5327-5338 [PMID: 37899788 DOI: 10.3748/wjg.v29.i37.5327]
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Submitted on:
October 07, 2023, 00:22
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Reader Comments:
It is very cleverly explained from the histological aspect of the benefits and disadvantages of semeglutide in the treatment of non-alcoholic fatty liver disease.
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Thank you very much for your comments.
Reader's ID:
00000246
Submitted on:
October 01, 2023, 08:37
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Reader Comment Standards for Published Articles:
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Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
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4 Background
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5 Methods
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6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
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Reader Comments:
NAFLD is a Worldwide Health Issue,yet there are currently no approved pharmacotherapies for the treatment of NAFLD and NASH.Glucagon-like peptide-1 receptor agonists (GLP-1RAs) can reduce HbA1c in patients with type 2 diabetes mellitus and reduce weight in overweight or obese patients.The purpose of this meta-study is highly meaningful, however it included only 3 studies and had significant heterogeneity among them.The readers should still face its results with caution. It is expected that the authors will update this meta-analysis in the future when sufficient studies become available
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Thank you very much for your comments.