Wang QQ, Zhou L, Qin G, Tan C, Zhou YC, Yao SK. Leukocyte immunoglobulin-like receptor B2 overexpression as a promising therapeutic target and noninvasive screening biomarker for colorectal cancer. World J Gastroenterol 2023; 29(37): 5313-5326 [PMID: 37899785 DOI: 10.3748/wjg.v29.i37.5313]
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07134057
Submitted on:
October 08, 2023, 03:51
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Reader Comments:
In this study, IHC confirmed that LILRB2 protein was significantly overexpressed in CRC, and increased LILRB2 protein expression was significantly associated with clinicopathological features such as low to moderate differentiation, lymph node metastasis, high TNM stage, and poor prognosis. In addition, the study further detected the expression of serum LILRB2, and the concentration of LILRB2 increased in the order of healthy control group, adenoma patients and CRC patients, and the difference was statistically significant. The sensitivity, specificity and AUC in the diagnosis of colorectal cancer were 89.74%, 88.89% and 0.95, respectively, which were better than those of traditional CEA and CA19-9. Moreover, ANGPTL2, a ligand of LILRB2, is highly expressed in CRC tissues and coexpressed with LILRB2 at both mRNA and protein levels, suggesting that their overexpression and interaction are associated with CRC progression. These results suggest that LILRB2 protein can be used as a potential therapeutic target and non-invasive screening biomarker for CRC.
In this study, flow cytometry was used to analyze LILRB2 expression in tissues, and traditional immunohistochemical staining was used to confirm the results of the two methods. These results further support that LILRB2 promotes the initiation and progression of colorectal cancer. This study also further analyzed the source of serum LILRB2 in patients with colorectal cancer, and provided ideas for clarifying the source of serum LILRB2. The serum expression levels of LILRB2 in patients with colorectal cancer before and after surgery and at different follow-up periods were dynamically monitored, which provided more comprehensive clinical data for understanding the expression of LILRB2. This study confirmed that LILRB2 can be used as a novel therapeutic target for colorectal cancer, with high potential for clinical translation, and provides new treatment opportunities for colorectal cancer.
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