Stella L, Santopaolo F, Gasbarrini A, Pompili M, Ponziani FR. Viral hepatitis and hepatocellular carcinoma: From molecular pathways to the role of clinical surveillance and antiviral treatment. World J Gastroenterol 2022; 28(21): 2251-2281 [PMID: 35800182 DOI: 10.3748/wjg.v28.i21.2251]
Reader's ID:
05116814
Submitted on:
June 27, 2022, 03:39
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
This review recommends appropriate monitoring through clinical biochemical score and regular ultrasound evaluation, and summarizes the virus and microenvironment of disease occurrence, as well as the pathophysiology and molecular pathways of chronic infection and carcinogenesis of HBV, HCV and HDV, so as to clarify the mechanism of tumorigenesis, cooperate with the design of future treatment schemes for this kind of cancer, and focus on the impact of clinical monitoring and antiviral treatment on the risk of HCC. The detailed description is carried out from multiple angles of each virus. The diagram is clear and easy to understand, the data is real and detailed, and the research and design data are cited many times. Conclusion HBV and HCV infected patients have a higher risk of carcinogenesis, mainly because of the interaction between viral proteome, transcriptome and host cell molecular pathways, involving inflammation and cell replication. And looking forward to the future, the new biomarkers and risk stratification system may help clinicians identify patients for closer follow-up, so as to achieve more personalized liver cancer monitoring methods.
Reply from the Editorial Office:
Thank you very much for your comments.
Author's Reply:
Replied on December 17, 2024, 09:37
Thank you