Yamamoto-Furusho JK, Parra-Holguín NN. Emerging therapeutic options in inflammatory bowel disease. World J Gastroenterol 2021; 27(48): 8242-8261 [PMID: 35068868 DOI: 10.3748/wjg.v27.i48.8242]
Reader's ID:
03663283
Submitted on:
December 30, 2021, 03:26
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
A well written computation of the therapeutic innovations that have evolved from the beneficial effects derived from selective inhibition of the immune system's Th 1 response. Crohn's disease (CD) is now accepted as being due to, in the absence of acquired immunity, fixation of of inherent immunity's Th1 response to Mycobacterium avium subsp. paratuberculosis and subsequent concentrated antigen (MAP)/ cytokine focal destruction of mucosal integrity. What is left under the umbrella of inflammatory diseases is ulcerative colitis (UC) which, without a diagnostic test of disease specificity, more probably than not, embraces a number of disease entities of diverging pathogenesis. The clinical efficacy studies that included Crohn's disease afflicted individuals need to be scrubbed in order to attain UC relevance. In most efficacy studies, it is not just to what extent a specific drug demonstrates a degree of efficacy versus placebo controls. It is why it fails or ultimately fails in the majority of cases that is left under-addressed.
Reply from the Editorial Office:
Thank you very much for your comments.