Mohamed DZ, Ghoneim MES, Abu-Risha SES, Abdelsalam RA, Farag MA. Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management. World J Gastroenterol 2021; 27(28): 4504-4535 [PMID: 34366621 DOI: 10.3748/wjg.v27.i28.4504]
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06121272
Submitted on:
August 05, 2021, 05:39
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Reader Comments:
It is a good work but it may have given erroneous descriptions of SARS-CoV-2-related direct liver injury pathways. SARS-CoV-2 does not cause direct viral hepatic damage, and the various impacts on liver injury observed in the presence of other comorbidities may be misleading. Good Luck
Reply from the Editorial Office:
Thank you very much for your comments.
Reader's ID:
05238162
Submitted on:
July 29, 2021, 17:27
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Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
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Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
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Does the author self-cite, omit, incorrectly cite and/or over-cite references?
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Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
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Reader Comments:
It was an excellent paper. It would have been perfect if GI and liver abnormalities of first wave vs second wave COVID patients be analysed and discussed based on geographical location of review articles and their corresponding wave patterns.
Another similar angle could have analysed and discussed w.r.t. similar variations in relation to real world geographical locations i.e. with altitudes, how these GI and liver abnormalities present.
I am sure these two points would have shown major different findings considering our local experiences in second COVID wave where major liver abnormalities were transaminities even more common than respiratory involvements. The hypothesis reason could be delta plus variant of SARS-CoV-2 affecting extra-pulmonary organs more than wave one COVID variants.
These viral phenotypes mark differences clinical phenotypes, need of the hour observations to be reviewed and published.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
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