Kalayarasan R, Narayanan S, Sahoo J, Mohan P. Impact of surgery for chronic pancreatitis on the risk of pancreatic cancer: Untying the Gordian knot. World J Gastroenterol 2021; 27(27): 4371-4382 [PMID: 34366610 DOI: 10.3748/wjg.v27.i27.4371]
Reader's ID:
03449438
Submitted on:
July 31, 2021, 00:52
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
Chronic pancreatitis (CP) is a significant risk role for pancreatic cancer (PC). The authors found that early surgical intervention for CP might have a protective role in the development of CP-related PC from previous studies. While the risk of PC is increased in patients with CP, it is still too low to recommend routine active screening or prophylactic surgery in all patients. Therefore, it is necessary to assign risk stratification to prophylactic surgery. Furthermore, they analyzed that the genetic and environmental factors could select patients for prophylactic surgery. Finally, the authors thought that precision medicine was future direction in CP-related PC.
In this literature review, highly relevant literature is presented and used in a relatively comprehensive manner. The authors are keen to observe the relationship between pancreatitis and pancreatic cancer. Moreover, through effective evaluation and synthesis of a series of literature, the authors put forward their own unique view, precision medicine, in CP-related PC. However, the logic is not tight enough. The authors should first explore the limitations of pancreatitis surgery and then highlight the importance of risk stratification for CP-related PC, instead of leaving the pancreatitis surgery at the end. Additionally, there are many pancreatic cancer subtypes, and the major subtypes associated with pancreatitis can be further explored. Surgery is not the first choice for chronic pancreatitis treatment. What should be done to prevent pancreatic cancer in high-risk CP patients who do not want prophylactic surgery.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.