Zhong M, Zhou L, Fang Z, Yao YY, Zou JP, Xiong JP, Xiang XJ, Deng J. Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway. World J Gastroenterol 2021; 27(26): 4221-4235 [PMID: 34326621 DOI: 10.3748/wjg.v27.i26.4221]
Reader's ID:
03383549
Submitted on:
July 18, 2021, 12:56
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
Comment on USP15 paper by Zhou M et al.
To date, it has been identified that deregulated gene expression, affecting the genes governing proliferation, programmed cell death plays a role in the occurrence of cancers. The expression of genes is regulated by such process of post-translational modification of histone or non-histone proteins including acetylation, methylation or deubiquitination on certain amino acid residues which are essential in maintaining the spatial configuration of these proteins. Deubiquitination targeting to the cancer related gene coding products may suppress or promote carcinogenesis. It has been shown that deubiquitination of a protein with dual activities, transforming growth factor (TGF)-beta catalyzed by ubiquitin specific protease 15 (USP-15) facilitates the progression of advanced malignant glioma by stabilizing the TGF b type I receptor (1). A protease with similar activity, but less structurally similar with USP-15, USP-19 regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (2). It has been noted that inhibitors of apoptosis (IAPs) are over-expressed and highlighted in a number of human tumors, including mucosa-associated lymphoid tissue (MALT)(3), hepatocellular carcinoma (4), esophageal and nasopharynx cancers (5, 6). In the present study, it has been described that highly expressed USP-15 is correlated with clinical characteristics (tumor size, depth of invasion, lymph node involvement, tumor-node-metastasis stage in gastric cancer; and its role in gastric carcinogenesis is exerted by regulation of wnt /beta-catenin pathway. We had previously reported a compound derived from natural product, dalbinol inhibits wnt/beta catenin pathway through regulation of protein degradation mediated by ubiquitin-proteasome pathway (7). The available data suggested that tumor suppression and antitumor therapy are targeted by different machinery regulating gene expression.
References:
1. Eichhorn PJ, Rodón L, Gonzàlez-Juncà A, et al. USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med. 2012;18:429-435
2. Mei Y., Hahn A.A., Hu S., Yang X. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. J. Biol. Chem. 2011; 286:35380-35387.
3. Isaacson P. G., Du M. Q. MALT lymphoma: from morphology to molecules. Nat. Rev. Cancer 2004; 4, 644–653.
4. Zender L, Spector MS, Xue W, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 2006; 125 (7): 1253–1267.
5. Imoto I, Yang ZQ, Pimkhaokham A, et al. Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer Res 2001; 61 (18): 6629–6634.
6. Friboulet L, Pioche-Durieu C, Rodriguez S, et al. Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosis. Neoplasia 2008; 10(11): 1183–1194;
7. Zhu X, Wu X, Cheng J, Liao H, Di X, Li L, Li R, Zhou Y, Zhang X. Dalbinol, a rotenoid from Amorpha fruticosa L., exerts anti-proliferative activity by facilitating beta-catenin degradation in hepatocellular carcinoma cells. Oncotarget. 2017; 8(29):47755-47766.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastroenterology.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Gastroenterology at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.