Colon capsule endoscopy (CCE) is a modern, non-invasive method for large bowel visualization, offering a less invasive alternative to traditional colonoscopy (TC). While TC remains the gold standard for comprehensive large bowel assessment, including the detection and treatment of various conditions, the effectiveness of CCE in detecting polyps is less established.

To systematically review and compare the polyp detection rates (PDR) of CCE and TC.

A systematic literature search was conducted using four scientific databases: CINAHL, MEDLINE via EBSCO, Cochrane Library, and MEDLINE/PubMed. A standardized search command was utilized to ensure consistency. Full papers were retrieved if they compared PDR between CCE and TC and involved patients over 18 years old. A meta-analysis was then conducted using the meta package in R software.

Initially, 339 articles were identified, with 128 duplicates and 15 non-English articles excluded, leaving 196 for screening. After further exclusions, 9 articles were included in the review. The meta-analysis revealed minimal differences in PDR between CCE and TC. The pooled PDR for TC was 0.61 (95%CI: 0.48–0.72), and for CCE, it was 0.61 (95%CI: 0.48–0.73). The overall comparison of the pooled PDR of both methods was 0.96 (95%CI: 0.90–1.02), indicating that CCE is non-inferior to TC.

CCE has emerged as a modern and safe diagnostic alternative to TC for polyp detection, demonstrating non-inferiority when compared to the conventional method.

• Colon capsule endoscopy
• Colonoscopy
• Polyp detection rate
• Polyp
• Adenoma
• Colorectal cancer

• artificial intelligence
• digestive healthcare
• gastroenterology
• medical device
• software

• artificial intelligence
• colon capsule endoscopy
• convolutional neural network

• Capsule endoscopy
• Colonoscopy
• Colon

The aim of this study was to evaluate the efficacy of high definition (HD) i-SCAN for colorectal polyp detection in screening colonoscopy.

We retrospectively analyzed the records of 501 patients who had undergone screening colonoscopy performed by three endoscopists with either HD i-SCAN (n=149) or standard white light (n=352) from January 2, 2014 through June 30, 2014. Patient information and inter-endoscopist variation as well as polyp number, endoscopic findings, and pathologic characteristics were reviewed.

The detection rates of colorectal and neoplastic polyps were significantly higher using HD i-SCAN than standard white light colonoscopy (52% vs. 38.1%, p=0.004 for colorectal polyps; and 37.2% vs. 27.9%, p=0.041 for neoplastic polyps). Analysis of endoscopic findings revealed no difference in detected polyp size between HD i-SCAN and standard white light colonoscopy (4.59±2.35 mm vs. 4.82±2.81 mm, p=0.739), but non-protruding polyps were more commonly detected by i-SCAN than by standard white light colonoscopy (24.6% vs. 13.5%, p=0.007).

Colonoscopy using HD i-SCAN had a significantly higher detection rate of colorectal polyps, including neoplastic polyps, because of improved sensitivity for detecting non-protruding lesions.

• Chromoendoscopy
• Colonic polyps
• Colonoscopy
• i-SCAN

• Video capsule endoscopy
• obscure gastrointestinal bleeding
• small bowel imaging

• Capsule Endoscopy
• Endoscopy, Gastrointestinal/methods
• Humans
• Inflammatory Bowel Diseases/drug therapy
• Inflammatory Bowel Diseases/pathology
• Intestinal Mucosa/pathology
• Magnetic Resonance Imaging
• Severity of Illness Index
• Wound Healing

• T32 DK007202 NIDDK NIH HHS
• 5T32DK007202-39 NIDDK NIH HHS

• Adult
• Aged
• Capsule Endoscopy/methods
• Capsule Endoscopy/standards
• Colonic Polyps/diagnosis
• Colonic Polyps/epidemiology
• Colonic Polyps/pathology
• Colorectal Neoplasms/diagnosis
• Colorectal Neoplasms/epidemiology
• Colorectal Neoplasms/pathology
• Early Detection of Cancer/statistics & numerical data
• Female
• Humans
• Male
• Mass Screening/methods
• Middle Aged
• Ontario
• Risk Factors

• Capsule endoscopy
• Crohn’s disease
• Inflammatory bowel disease
• Mucosal healing
• Small bowel diseases

• Adolescent
• Adult
• Capsule Endoscopes
• Capsule Endoscopy/instrumentation
• Colon/drug effects
• Colon/pathology
• Crohn Disease/drug therapy
• Crohn Disease/pathology
• Female
• Humans
• Immunosuppressive Agents/therapeutic use
• Intestinal Mucosa/drug effects
• Intestinal Mucosa/pathology
• Intestine, Small/drug effects
• Intestine, Small/pathology
• Male
• Middle Aged
• Predictive Value of Tests
• Remission Induction
• Retrospective Studies
• Time Factors
• Treatment Outcome
• Wound Healing/drug effects
• Young Adult

• Barrett's oesophagus
• bowel preparation
• colon capsule
• colorectal polyps
• esophageal capsule
• esophageal varices

• Image enhancement
• Localization
• Locomotion
• Magnetic manipulation
• Medical robotics

• R01 EB018992 NIBIB NIH HHS

Screening has a central role in colorectal cancer (CRC) control. Different screening tests are effective in reducing CRC-specific mortality. Influence on cancer incidence depends on test sensitivity for pre-malignant lesions, ranging from almost no influence for guaiac-based fecal occult blood testing (gFOBT) to an estimated reduction of 66–90% for colonoscopy. Screening tests detect lesions indirectly in the stool [gFOBT, fecal immunochemical testing (FIT), and fecal DNA] or directly by colonic inspection [flexible sigmoidoscopy, colonoscopy, CT colonography (CTC), and capsule endoscopy]. CRC screening is cost-effective compared to no screening but no screening strategy is clearly better than the others. Stool tests are the most widely used in worldwide screening interventions. FIT will soon replace gFOBT. The use of colonoscopy as a screening test is increasing and this strategy has superseded all alternatives in the US and Germany. Despite its undisputed importance, CRC screening is under-used and participation rarely reaches 70% of target population. Strategies to increase participation include ensuring recommendation by physicians, introducing organized screening and developing new, more acceptable tests. Available evidence for DNA fecal testing, CTC, and capsule endoscopy is reviewed.

• CT colonography
• advanced adenoma
• capsule endoscopy
• colorectal cancer
• fecal tests
• flexible sigmoidoscopy
• screening
• total colonoscopy

• Anxiety
• Colonoscopy
• Conscious sedation
• Discomfort
• Fear
• Pain

Colorectal cancer (CRC) is the second most common cancer in Europe and its incidence is steadily increasing. This trend could be reversed through timely secondary prevention (screening). In the last twenty years, CRC screening programs across Europe have experienced considerable improvements (fecal occult blood testing; transition from opportunistic to population based program settings). The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality rates. Each year, approximately 8000 people are diagnosed with CRC and some 4000 die from this malignancy. Twenty years ago, the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in 2000. Originally, this program was based on the guaiac fecal occult blood test (FOBT) offered by general practitioners, followed by colonoscopy in cases of FOBT positivity. The program has continuously evolved, namely with the implementation of immunochemical FOBTs and screening colonoscopy, as well as the involvement of gynecologists. Since the establishment of the Czech CRC Screening Registry in 2006, 2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening program. The overall program expanded to cover 25.0% of the target population by 2011. However, stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation, which is currently being prepared.

• Colorectal cancer
• Population-based screening program
• Colonoscopy
• Fecal occult blood test

• Colonoscopy
• Colorectal Neoplasms/diagnosis
• Colorectal Neoplasms/epidemiology
• Czech Republic
• Early Detection of Cancer/methods
• Europe
• Feces
• Female
• Humans
• Incidence
• Male
• Mass Screening/methods
• Medical Oncology/trends
• Occult Blood
• Quality Control
• Registries

• cancer prevention
• capsule endoscopy
• colon
• colonoscopy
• colorectal cancer

• Colonoscopy
• Computer-assisted colonoscopy
• Gastrointestinal endoscopy
• Robotics

• capsule colonoscopy
• crc screening
• robotic capsules
• wireless capsule endoscopy
• wireless insufflation

• Acetic Acid/chemistry
• Animals
• Bicarbonates/chemistry
• Capsule Endoscopes
• Capsule Endoscopy/instrumentation
• Capsule Endoscopy/methods
• Citric Acid/chemistry
• Equipment Design
• Feasibility Studies
• Insufflation/instrumentation
• Intestines/surgery
• Models, Biological
• Phantoms, Imaging
• Robotics/instrumentation
• Swine
• Wireless Technology

• UL1 TR000445 NCATS NIH HHS
• 2 UL1 TR000445-06 NCATS NIH HHS

Colorectal cancer is the third most common cancer in men and the second most common cancer in women worldwide. Diagnosing colorectal has been increasingly successful due to advances in technology. Flexible endoscopy is considered to be an effective method for early diagnosis and treatment of gastrointestinal cancer, making it a popular choice for screening programs. However, millions of people who may benefit from endoscopic colorectal cancer screening fail to have the procedure performed. Main reasons include psychological barriers due to the indignity of the procedure, fear of procedure related pain, bowel preparation discomfort, and potential need for sedation. Therefore, an urgent need for new technologies addressing these issues clearly exists. In this review, we discuss a set of advanced endoscopic technologies for colorectal cancer screening that are either already available or close to clinical trial. In particular, we focus on visual-inspection-only advanced flexible colonoscopes, interventional colonoscopes with alternative propulsion mechanisms, wireless capsule colonoscopy, and technologies for intraprocedural bowel cleansing. Many of these devices have the potential to reduce exam related patient discomfort, obviate the need for sedation, increase diagnostic yield, reduce learning curves, improve access to screening, and possibly avert the need for a bowel preparation.

• Endoscopy
• Technology
• Capsule colonoscopy
• Colorectal cancer
• Screening