• ERCP
• endoscopic ultrasound
• endoscopy
• pancreatic cancer
• pancreatic cancer screening
• radiofrequency ablation

• Artificial intelligence
• early detection
• machine learning
• pancreatic cancer
• prognosis prediction

• Humans
• Artificial Intelligence
• Algorithms
• Pancreatic Neoplasms/diagnosis
• Biomarkers, Tumor

• Pancreas
• Quantitative
• Radiomics
• Texture analysis

• artificial intelligence
• artificial neural network
• convolutional neural network
• endoscopic ultrasonography
• pancreatic cancer
• support vector machine

The development of artificial intelligence (AI) has increased dramatically in the last 20 years, with clinical applications progressively being explored for most of the medical specialties. The field of gastroenterology and hepatology, substantially reliant on vast amounts of imaging studies, is not an exception. The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions (e.g., identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus, pancreatic malignancies), detection of lesions (e.g., polyp identification and classification, small-bowel bleeding lesion on capsule endoscopy, pancreatic cystic lesions), development of objective scoring systems for risk stratification, predicting disease prognosis or treatment response [e.g., determining survival in patients post-resection of hepatocellular carcinoma), determining which patients with inflammatory bowel disease (IBD) will benefit from biologic therapy], or evaluation of metrics such as bowel preparation score or quality of endoscopic examination. The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract, including the upper, middle and lower tracts; IBD; the hepatobiliary system; and the pancreas, discussing the findings and clinical applications, as well as outlining the current limitations and future directions in this field.

• Artificial intelligence
• Machine learning
• Deep learning
• Clinical applications
• Gastroenterology

• Artificial Intelligence
• Barrett Esophagus
• Diagnostic Imaging
• Endoscopy
• Gastroenterology
• Humans

Preoperative diagnosis rate of pancreatic cancer has increased year by year. The prognosis of pancreatic cancer patients with unexpected liver metastasis found by intraoperative exploration is very poor, and there is no effective and unified treatment strategy.

To evaluate the therapeutic effect of radioactive ¹²⁵I seed implantation for pancreatic cancer patients with unexpected liver metastasis.

The demographics and perioperative outcomes of patients who underwent ¹²⁵I seed implantation to treat pancreatic cancer with unexpected liver metastasis between January 1, 2017 and June 1, 2019 were retrospectively analyzed. During the operation, ¹²⁵I seeds were implanted into the pancreatic tumor under the guidance of intraoperative ultrasound, with a spacing of 1.5 cm and a row spacing of 1.5 cm. For patients with obstructive jaundice and digestive tract obstruction, choledochojejunostomy and gastroenterostomy were performed simultaneously. After operation, the patients were divided into a non-chemotherapy group and a chemotherapy group that received gemcitabine combined with albumin-bound paclitaxel treatment.

Preoperative imaging evaluation of all patients in this study showed that the tumor was resectable without liver metastasis. There were 26 patients in this study, including 18 males and 8 females, aged 60.5 ± 9.7 years. The most common tumor site was the pancreatic head (17, 65.4%), followed by the pancreatic neck and body (6, 23.2%) and pancreatic tail (3, 11.4%). Fourteen patients (53.8%) underwent palliative surgery and postoperative pain relief occurred in 22 patients (84.6%). The estimated blood loss in operation was 148.3 ± 282.1 mL and one patient received blood transfusion. The postoperative hospital stay was 7.6 ± 2.8 d. One patient had biliary fistula, one had pancreatic fistula, and all recovered after conservative treatment. After operation, 7 patients received chemotherapy and 19 did not. The 1-year survival rate was significantly higher in patients who received chemotherapy than in those who did not (68.6% vs 15.8%, P = 0.012). The mean overall survival of patients in the chemotherapy group and non-chemotherapy group was 16.3 mo and 10 mo, respectively (χ² = 7.083, P = 0.008).

Radioactive ¹²⁵I seed implantation combined with postoperative chemotherapy can prolong the survival time and relieve pain of pancreatic cancer patients with unexpected liver metastasis.

• Pancreatic cancer
• Liver metastases
• Radioactive ¹²⁵I seeds
• Radiotherapy
• Permanent implantation
• Therapeutic effect

• Biliary
• Endoscopy
• Neoplasms < gastroenterology
• Pancreas < gastroenterology
• Pancreatobiliary (ERCP) < gastroenterology

• Magnetic resonance imaging
• Pancreas
• Radiomics

Pancreatic cancer is one of the common malignant tumors of the digestive system, and radical resection is the first choice of treatment for pancreatic cancer. If patients with locally advanced pancreatic cancer cannot be treated in time and effectively, their disease often develops rapidly and their survival period is very short.

To evaluate the therapeutic effect of ¹²⁵I seed implantation in patients with locally advanced pancreatic cancer.

The demographics and perioperative outcomes of a consecutive series of patients who underwent ¹²⁵I seed implantation to treat locally advanced pancreatic cancer between January 1, 2017 and June 30, 2019 were retrospectively analyzed. According to the results of preoperative computed tomography or magnetic resonance imaging, the treatment planning system was used to determine the area and number of ¹²⁵I seeds implanted. During the operation, ¹²⁵I seeds were implanted into the tumor under the guidance of intraoperative ultrasound, with a spacing of 1.5 cm and a row spacing of 1.5 cm. For patients with obstructive jaundice and digestive tract obstruction, choledochojejunostomy and gastroenterostomy were performed simultaneously. After operation, the patients were divided into a non-chemotherapy group and a chemotherapy group that received gemcitabine combined with albumin-bound paclitaxel treatment.

Among the 50 patients, there were 29 males and 21 females, with a mean age of 56.9 ± 9.8 years. The main reason for the failure of radical resection was superior mesenteric artery invasion (37, 74%), followed by superior mesenteric vein invasion (33, 66%). Twenty-one (62%) patients underwent palliative surgery and postoperative pain relief occurred in 40 (80%) patients. The estimated blood loss in operation was 107.4 ± 115.3 mL and none of the patient received blood transfusion. The postoperative hospital stay was 7.5 ± 4.2 d; one patient had biliary fistula and three had pancreatic fistula, all of whom recovered after conservative treatment. After operation, 26 patients received chemotherapy and 24 did not. The 1-year survival rate was significantly higher in patients who received chemotherapy than in those who did not (60.7% vs 35.9%, P = 0.034). The mean overall survival of patients of the chemotherapy group and non-chemotherapy group was 14 and 11 mo, respectively (χ² = 3.970, P = 0.046).

Radioactive ¹²⁵I seed implantation combined with postoperative chemotherapy can prolong the survival time, relieve pain, and improve the quality of life of patients with locally advanced pancreatic cancer.

• Pancreatic cancer
• Radioactive ¹²⁵I seeds
• Radiotherapy
• Permanent implantation

• Radioactive iodine-125
• apoptosis
• brachytherapy
• chemotherapy
• pancreatic cancer

• Animals
• Apoptosis
• Brachytherapy/adverse effects
• Brachytherapy/methods
• Cell Line, Tumor
• Dose-Response Relationship, Radiation
• Humans
• Iodine Radioisotopes/adverse effects
• Iodine Radioisotopes/therapeutic use
• Pancreatic Neoplasms/radiotherapy
• Pancreatic Neoplasms/surgery
• Patient Safety
• Prognosis
• Treatment Outcome
• Pancreatic Neoplasms

This study aimed to investigate the outcomes of permanent Iodine-125 (¹²⁵I) radiotherapy for patients with unresectable retroperitoneal malignant tumor.

Twenty-six patients with retroperitoneal malignant tumors were implanted with ¹²⁵I seeds under ultrasound guidance from June 2012 to June 2015. The patients were then followed up for 3 to 36 months after the implantation. During the follow-up, pain relief, control of tumor growth, over survival rate, and complications were evaluated.

Most of the patients (90%, 24/26) suffered from mild to severe pain before ¹²⁵I seed treatment. After 1-month treatment, 16 patients had 100% pain relief, 4 patients had at least 50% pain relief, and 4 patients had no response, showing 83.3% of pain relief response. Results of computed tomography scan after 2-month ¹²⁵I treatment indicated that 3 patients had complete remission in the tumor size, 20 patients had partial remission in tumor size, 2 patients were stable, and 1 patient had progressive disease, accounting for 88.4% response in tumor size remission. The median survival of the 26 patients was 11 months. The 1-year and 2-year overall survival rates were 46% and 27%, respectively. The median survival of the 5 patients with pancreatic cancer was 9.4 months. None of the patients had any severe complications.

¹²⁵I implantation could effectively relieve the pain in the patients with advanced primary or metastatic retroperitoneal malignant tumors and suppress local tumor progress.

• overall survival
• radioactive iodine-125 seed implantation
• retroperitoneal malignant tumors

AIM: To characterize the clinical, radiological, endoscopic and pathological features of intestinal tuberculosis (ITB) and primary small intestinal lymphoma (PSIL).

METHODS: This was a retrospective study from February 2005 to October 2012 of patients with a diagnosis of ITB (n = 41) or PSIL (n = 37). All patients with ITB or PSIL underwent computed tomography (CT) and pathological examination. Thirty-five patients with ITB and 32 patients with PSIL underwent endoscopy. These patients were followed for a further 18 mo to ascertain that the diagnosis had not changed. Clinical, endoscopic, CT and pathological features were compared between ITB and PSIL patients.

RESULTS: Night sweating, fever, pulmonary TB and ascites were discovered significantly more often in ITB than in PSIL patients (P < 0.05), however, abdominal mass, hematochezia and intestinal perforation were found significantly more frequently in PSIL than in ITB patients (P < 0.05). Ring-like and rodent-like ulcers occurred significantly more often in ITB than in PSIL patients (P < 0.05), however, enterorrhagia and raised lesions were significantly more frequent in PSIL than in ITB patients (P < 0.05). The rate of granuloma was significantly higher in ITB than in PSIL patients (87.8% vs 13.5%, χ² = 43.050, P < 0.05), and the incidence of confluent granulomas with caseous necrosis was significantly higher in ITB than in PSIL patients (47.2% vs 0.0%, χ² = 4.034, P < 0.05). Multi-segmental lesions, mural stratification, mural gas sign, and intestinal stricture were more frequent in ITB than in PSIL patients (P < 0.05), however, a single-layer thickening of bowel wall, single segmental lesions, and intussusception were more common in PSIL than in ITB patients (P < 0.05). Necrotic lymph nodes, comb sign and inflammatory mass were more frequent in ITB than in PSIL patients (P < 0.05). The bowel wall enhancement in ITB patients was greater than that in PSIL patients (P < 0.05), while the thickening and lymph node enlargement in PSIL patients were higher than those in ITB patients (P < 0.05).

CONCLUSION: Combined evaluation of clinical, radiological, endoscopic and pathological features is the key to differentiation between ITB and PSIL.

• Intestinal tuberculosis
• Primary small intestinal lymphoma
• Clinical features
• Endoscopic features
• Computed tomography

• Adult
• Diagnosis, Differential
• Endoscopy
• Humans
• Inflammation
• Intestinal Neoplasms/diagnosis
• Intestines/pathology
• Lymphoma/diagnosis
• Male
• Retrospective Studies
• Tomography, X-Ray Computed
• Treatment Outcome
• Tuberculosis, Gastrointestinal/diagnosis