Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Machner A, Baier A, Wille A, Drynda S, Pap G, Drynda A, Mawrin C, Bühling F, Gay S, Neumann W, Pap T. Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-alpha in periarticular tenocytes from patients with knee joint osteoarthritis. Arthritis Res Ther 2003;5:R253-61. [PMID: 12932288 PMCID: PMC193726 DOI: 10.1186/ar789] [Citation(s) in RCA: 29] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/13/2003] [Revised: 05/15/2003] [Accepted: 06/03/2003] [Indexed: 02/07/2023] Open

For:	Machner A, Baier A, Wille A, Drynda S, Pap G, Drynda A, Mawrin C, Bühling F, Gay S, Neumann W, Pap T. Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-alpha in periarticular tenocytes from patients with knee joint osteoarthritis. Arthritis Res Ther 2003;5:R253-61. [PMID: 12932288 PMCID: PMC193726 DOI: 10.1186/ar789] [Citation(s) in RCA: 29] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/13/2003] [Revised: 05/15/2003] [Accepted: 06/03/2003] [Indexed: 02/07/2023] Open

Number

Cited by Other Article(s)

Hatzikotoulas K, Southam L, Stefansdottir L, Boer CG, McDonald ML, Pett JP, Park YC, Tuerlings M, Mulders R, Barysenka A, Arruda AL, Tragante V, Rocco A, Bittner N, Chen S, Horn S, Srinivasasainagendra V, To K, Katsoula G, Kreitmaier P, Tenghe AMM, Gilly A, Arbeeva L, Chen LG, de Pins AM, Dochtermann D, Henkel C, Höijer J, Ito S, Lind PA, Lukusa-Sawalena B, Minn AKK, Mola-Caminal M, Narita A, Nguyen C, Reimann E, Silberstein MD, Skogholt AH, Tiwari HK, Yau MS, Yue M, Zhao W, Zhou JJ, Alexiadis G, Banasik K, Brunak S, Campbell A, Cheung JTS, Dowsett J, Faquih T, Faul JD, Fei L, Fenstad AM, Funayama T, Gabrielsen ME, Gocho C, Gromov K, Hansen T, Hudjashov G, Ingvarsson T, Johnson JS, Jonsson H, Kakehi S, Karjalainen J, Kasbohm E, Lemmelä S, Lin K, Liu X, Loef M, Mangino M, McCartney D, Millwood IY, Richman J, Roberts MB, Ryan KA, Samartzis D, Shivakumar M, Skou ST, Sugimoto S, Suzuki K, Takuwa H, Teder-Laving M, Thomas L, Tomizuka K, Turman C, Weiss S, Wu TT, Zengini E, Zhang Y, Ferreira MAR, Babis G, Baras A, Barker T, Carey DJ, Cheah KSE, Chen Z, Cheung JPY, Daly M, de Mutsert R, Eaton CB, et alHatzikotoulas K, Southam L, Stefansdottir L, Boer CG, McDonald ML, Pett JP, Park YC, Tuerlings M, Mulders R, Barysenka A, Arruda AL, Tragante V, Rocco A, Bittner N, Chen S, Horn S, Srinivasasainagendra V, To K, Katsoula G, Kreitmaier P, Tenghe AMM, Gilly A, Arbeeva L, Chen LG, de Pins AM, Dochtermann D, Henkel C, Höijer J, Ito S, Lind PA, Lukusa-Sawalena B, Minn AKK, Mola-Caminal M, Narita A, Nguyen C, Reimann E, Silberstein MD, Skogholt AH, Tiwari HK, Yau MS, Yue M, Zhao W, Zhou JJ, Alexiadis G, Banasik K, Brunak S, Campbell A, Cheung JTS, Dowsett J, Faquih T, Faul JD, Fei L, Fenstad AM, Funayama T, Gabrielsen ME, Gocho C, Gromov K, Hansen T, Hudjashov G, Ingvarsson T, Johnson JS, Jonsson H, Kakehi S, Karjalainen J, Kasbohm E, Lemmelä S, Lin K, Liu X, Loef M, Mangino M, McCartney D, Millwood IY, Richman J, Roberts MB, Ryan KA, Samartzis D, Shivakumar M, Skou ST, Sugimoto S, Suzuki K, Takuwa H, Teder-Laving M, Thomas L, Tomizuka K, Turman C, Weiss S, Wu TT, Zengini E, Zhang Y, Ferreira MAR, Babis G, Baras A, Barker T, Carey DJ, Cheah KSE, Chen Z, Cheung JPY, Daly M, de Mutsert R, Eaton CB, Erikstrup C, Furnes ON, Golightly YM, Gudbjartsson DF, Hailer NP, Hayward C, Hochberg MC, Homuth G, Huckins LM, Hveem K, Ikegawa S, Ishijima M, Isomura M, Jones M, Kang JH, Kardia SLR, Kloppenburg M, Kraft P, Kumahashi N, Kuwata S, Lee MTM, Lee PH, Lerner R, Li L, Lietman SA, Lotta L, Lupton MK, Mägi R, Martin NG, McAlindon TE, Medland SE, Michaëlsson K, Mitchell BD, Mook-Kanamori DO, Morris AP, Nabika T, Nagami F, Nelson AE, Ostrowski SR, Palotie A, Pedersen OB, Rosendaal FR, Sakurai-Yageta M, Schmidt CO, Sham PC, Singh JA, Smelser DT, Smith JA, Song YQ, Sørensen E, Tamiya G, Tamura Y, Terao C, Thorleifsson G, Troelsen A, Tsezou A, Uchio Y, Uitterlinden AG, Ullum H, Valdes AM, van Heel DA, Walters RG, Weir DR, Wilkinson JM, Winsvold BS, Yamamoto M, Zwart JA, Stefansson K, Meulenbelt I, Teichmann SA, van Meurs JBJ, Styrkarsdottir U, Zeggini E. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature 2025:10.1038/s41586-025-08771-z. [PMID: 40205036 DOI: 10.1038/s41586-025-08771-z] [Show More Authors] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/17/2024] [Accepted: 02/11/2025] [Indexed: 04/11/2025]

Affiliation(s)

Konstantinos Hatzikotoulas Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Lorraine Southam Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Lilja Stefansdottir deCODE Genetics/Amgen, Reykjavik, Iceland
Cindy G Boer Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands
Merry-Lynn McDonald Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA Department of Genetics, School of Medicine, UAB, Birmingham, AL, USA
J Patrick Pett Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK
Young-Chan Park Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Margo Tuerlings Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Rick Mulders Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Andrei Barysenka Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Ana Luiza Arruda Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Vinicius Tragante deCODE Genetics/Amgen, Reykjavik, Iceland
Alison Rocco Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA
Norbert Bittner Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Shibo Chen Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Susanne Horn Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Vinodh Srinivasasainagendra Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA
Ken To Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK Department of Surgery, University of Cambridge, Cambridge, UK
Georgia Katsoula Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Peter Kreitmaier Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Amabel M M Tenghe Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany
Arthur Gilly Regeneron Genetics Center, Tarrytown, NY, USA
Liubov Arbeeva Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Lane G Chen Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong
Agathe M de Pins Icahn School of Medicine at Mount Sinai, New York, NY, USA
Daniel Dochtermann Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA
Cecilie Henkel Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
Jonas Höijer Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Shuji Ito Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
Penelope A Lind Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
Bitota Lukusa-Sawalena Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA
Aye Ko Ko Minn Tohoku University Graduate School of Medicine, Sendai, Japan
Marina Mola-Caminal Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Akira Narita Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Chelsea Nguyen Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA
Ene Reimann Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Micah D Silberstein Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Anne-Heidi Skogholt HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Hemant K Tiwari Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA
Michelle S Yau Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA
Ming Yue School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong
Wei Zhao Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Jin J Zhou Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA
George Alexiadis 1st Department of Orthopaedics, KAT General Hospital, Athens, Greece
Karina Banasik Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Søren Brunak Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Archie Campbell Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK
Jackson T S Cheung Faculty of Medical Sciences, University College London, London, UK
Joseph Dowsett Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark
Tariq Faquih Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Jessica D Faul Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
Lijiang Fei Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK
Anne Marie Fenstad The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
Takamitsu Funayama Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Maiken E Gabrielsen HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Chinatsu Gocho Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Kirill Gromov Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
Thomas Hansen Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Glostrup, Denmark
Georgi Hudjashov Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Thorvaldur Ingvarsson Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Jessica S Johnson Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Helgi Jonsson Faculty of Medicine, University of Iceland, Reykjavik, Iceland Department of Medicine, Landspitali The National University Hospital of Iceland, Reykjavik, Iceland
Saori Kakehi Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Juntendo University, Tokyo, Japan
Juha Karjalainen Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Elisa Kasbohm Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
Susanna Lemmelä Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Finnish Institute for Health and Welfare (THL), Helsinki, Finland
Kuang Lin Nuffield Department of Population Health, University of Oxford, Oxford, UK
Xiaoxi Liu Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
Marieke Loef Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Massimo Mangino Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK
Daniel McCartney Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK
Iona Y Millwood Nuffield Department of Population Health, University of Oxford, Oxford, UK
Joshua Richman Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA Department of Surgery, School of Medicine, UAB, Birmingham, AL, USA
Mary B Roberts Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA
Kathleen A Ryan Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Dino Samartzis Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
Manu Shivakumar Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Søren T Skou Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Denmark
Sachiyo Sugimoto Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Ken Suzuki Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
Hiroshi Takuwa Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan
Maris Teder-Laving Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Laurent Thomas HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Kohei Tomizuka Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
Constance Turman Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Stefan Weiss Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
Tian T Wu Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong
Eleni Zengini 4th Psychiatric Department, Dromokaiteio Psychiatric Hospital, Haidari, Athens, Greece
Yanfei Zhang Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA
Manuel Allen Revez Ferreira Regeneron Genetics Center, Tarrytown, NY, USA
George Babis 2nd Department of Orthopaedics, National and Kapodistrian University of Athens, Medical School, 'Konstantopouleio' Hospital, Athens, Greece
Aris Baras Regeneron Genetics Center, Tarrytown, NY, USA
Tyler Barker Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA Intermountain Healthcare, Precision Genomics, Salt Lake City, UT, USA Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA
David J Carey Department of Genomic Health, Geisinger, Danville, PA, USA
Kathryn S E Cheah School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong
Zhengming Chen Nuffield Department of Population Health, University of Oxford, Oxford, UK
Jason Pui-Yin Cheung Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China
Mark Daly Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Renée de Mutsert Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Charles B Eaton Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA
Christian Erikstrup Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Ove Nord Furnes The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway Department of Clinical Medicine, University of Bergen, Bergen, Norway
Yvonne M Golightly Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA University of Nebraska Medical Center, Omaha, NE, USA
Daniel F Gudbjartsson deCODE Genetics/Amgen, Reykjavik, Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
Nils P Hailer Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Caroline Hayward MRC Human Genetics Unit IGC, University of Edinburgh, Edinburgh, UK
Marc C Hochberg Department of Epidemiology and Public Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Georg Homuth Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
Laura M Huckins Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA
Kristian Hveem HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Levanger, Norway Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
Shiro Ikegawa Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
Muneaki Ishijima Department of Medicine for Orthopaedics and Motor Organ, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
Minoru Isomura Faculty of Human Sciences, Shimane University, Matsue, Japan
Marcus Jones Regeneron Genetics Center, Tarrytown, NY, USA
Jae H Kang Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Sharon L R Kardia Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Margreet Kloppenburg Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Peter Kraft Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Nobuyuki Kumahashi Department of Orthopedic Surgery, Matsue Red Cross Hospital, Matsue, Japan
Suguru Kuwata Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan
Ming Ta Michael Lee Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA
Phil H Lee Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Boston, USA
Robin Lerner Blizard Institute, Queen Mary University of London, London, UK
Liming Li Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China
Steve A Lietman Musculoskeletal Institute, Geisinger, Danville, PA, USA
Luca Lotta Regeneron Genetics Center, Tarrytown, NY, USA
Michelle K Lupton School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia Neurogenetics and Dementia, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia
Reedik Mägi Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Nicholas G Martin Genetic Epidemiology, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Timothy E McAlindon Division of Rheumatology, Allergy, & Immunology, Tufts Medical Center, Boston, MA, USA
Sarah E Medland Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia School of Psychology, University of Queensland, Brisbane, Queensland, Australia Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia
Karl Michaëlsson Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Braxton D Mitchell Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Dennis O Mook-Kanamori Department of Public Health, Leiden University Medical Center, Leiden, The Netherlands
Andrew P Morris Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK
Toru Nabika Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan
Fuji Nagami Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Amanda E Nelson Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Sisse Rye Ostrowski Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Aarno Palotie Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Ole Birger Pedersen Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Department of Clinical Immunology, Zealand University Hospital - Køge, Køge, Denmark
Frits R Rosendaal Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Mika Sakurai-Yageta Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Carsten Oliver Schmidt Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
Pak Chung Sham Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong
Jasvinder A Singh Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA Division of Rheumatology and Clinical Immunology, Department of Medicine at the School of Medicine, UAB, Birmingham, AL, USA Medicine Service, Michale E. DeBakey VA Medical Center, Houston, TX, USA Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Diane T Smelser Department of Genomic Health, Geisinger, Danville, PA, USA
Jennifer A Smith Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
You-Qiang Song School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong
Erik Sørensen Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark
Gen Tamiya Tohoku University Graduate School of Medicine, Sendai, Japan Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan Statistical Genetics Team, Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan
Yoshifumi Tamura Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
Chikashi Terao Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
Gudmar Thorleifsson deCODE Genetics/Amgen, Reykjavik, Iceland
Anders Troelsen Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
Aspasia Tsezou Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa, Greece
Yuji Uchio Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan
A G Uitterlinden Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands
Henrik Ullum Statens Serum Institute, Copenhagen, Denmark
Ana M Valdes Faculty of Medicine & Health Sciences, School of Medicine, University of Nottingham, Nottingham, UK
David A van Heel Blizard Institute, Queen Mary University of London, London, UK
Robin G Walters Nuffield Department of Population Health, University of Oxford, Oxford, UK
David R Weir Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
J Mark Wilkinson School of Medicine and Population Health, The University of Sheffield, Sheffield, UK
Bendik S Winsvold HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway Department of Neurology, Oslo University Hospital, Oslo, Norway
Masayuki Yamamoto Tohoku University Graduate School of Medicine, Sendai, Japan Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
John-Anker Zwart HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
Kari Stefansson deCODE Genetics/Amgen, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Ingrid Meulenbelt Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Sarah A Teichmann Department of Medicine & Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
Joyce B J van Meurs Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands
Unnur Styrkarsdottir deCODE Genetics/Amgen, Reykjavik, Iceland
Eleftheria Zeggini Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany.

Collapse

Jiang F, Zhao H, Zhang P, Bi Y, Zhang H, Sun S, Yao Y, Zhu X, Yang F, Liu Y, Xu S, Yu T, Xiao X. Challenges in tendon-bone healing: emphasizing inflammatory modulation mechanisms and treatment. Front Endocrinol (Lausanne) 2024;15:1485876. [PMID: 39568806 PMCID: PMC11576169 DOI: 10.3389/fendo.2024.1485876] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/25/2024] [Accepted: 10/11/2024] [Indexed: 11/22/2024] Open

Hengtrakool P, Leearamwat N, Sengprasert P, Wongphoom J, Chaichana T, Taweevisit M, Ngarmukos S, Tanavalee A, Palaga T, Reantragoon R. Infrapatellar fat pad adipose tissue-derived macrophages display a predominant CD11c+CD206+ phenotype and express genotypes attributable to key features of OA pathogenesis. Front Immunol 2024;15:1326953. [PMID: 38361943 PMCID: PMC10867170 DOI: 10.3389/fimmu.2024.1326953] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/24/2023] [Accepted: 01/03/2024] [Indexed: 02/17/2024] Open

Abstract

Objectives

In knee osteoarthritis (OA), macrophages are the most predominant immune cells that infiltrate synovial tissues and infrapatellar fat pads (IPFPs). Both M1 and M2 macrophages have been described, but their role in OA has not been fully investigated. Therefore, we investigated macrophage subpopulations in IPFPs and synovial tissues of knee OA patients and their correlation with disease severity, examined their transcriptomics, and tested for factors that influenced their polarization.

Methods

Synovial tissues and IPFPs were obtained from knee OA patients undergoing total knee arthroplasty. Macrophages isolated from these joint tissues were characterized via flow cytometry. Transcriptomic profiling of each macrophage subpopulations was performed using NanoString technology. Peripheral blood monocyte-derived macrophages (MDMs) were treated with synovial fluid and synovial tissue- and IPFP-conditioned media. Synovial fluid-treated MDMs were treated with platelet-rich plasma (PRP) and its effects on macrophage polarization were observed.

Results

Our findings show that CD11c+CD206+ macrophages were predominant in IPFPs and synovial tissues compared to other macrophage subpopulations (CD11c+CD206-, CD11c-CD206+, and CD11c-CD206- macrophages) of knee OA patients. The abundance of macrophages in IPFPs reflected those in synovial tissues but did not correlate with disease severity as determined from Mankin scoring of cartilage destruction. Our transcriptomics data demonstrated highly expressed genes that were related to OA pathogenesis in CD11c+CD206+ macrophages than CD11c+CD206-, CD11c-CD206+, and CD11c-CD206- macrophages. In addition, MDMs treated with synovial fluid, synovial tissue-conditioned media, or IPFP-conditioned media resulted in different polarization profiles of MDMs. IPFP-conditioned media induced increases in CD86+CD206+ MDMs, whereas synovial tissue-conditioned media induced increases in CD86+CD206- MDMs. Synovial fluid treatment (at 1:8 dilution) induced a very subtle polarization in each macrophage subpopulation. PRP was able to shift macrophage subpopulations and partially reverse the profiles of synovial fluid-treated MDMs.

Conclusion

Our study provides an insight on the phenotypes and genotypes of macrophages found in IPFPs and synovial tissues of knee OA patients. We also show that the microenvironment plays a role in driving macrophages to polarize differently and shifting macrophage profiles can be reversed by PRP.

Collapse

Chen K, Tao H, Zhu P, Chu M, Li X, Shi Y, Zhang L, Xu Y, Lv S, Huang L, Huang W, Geng D. ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis. Arthritis Res Ther 2024;26:20. [PMID: 38218854 PMCID: PMC10787439 DOI: 10.1186/s13075-023-03238-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2023] [Accepted: 12/13/2023] [Indexed: 01/15/2024] Open

Affiliation(s)

Kai Chen Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China Department of Orthopedics, Hai'an People's Hospital, Zhongba Road 17, Hai'an, Jiangsu, China
Huaqiang Tao Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China
Pengfei Zhu Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China
Miao Chu Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China Department of Orthopedics, Yixing Peoples's Hospital, Xincheng Road 1588, Yixing, Jiangsu, China
Xueyan Li Anesthesiology department, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Guangjj Road 242, Suzhou, Jiangsu, China
Yi Shi Anesthesiology department, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Guangjj Road 242, Suzhou, Jiangsu, China
Liyuan Zhang Anesthesiology department, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Guangjj Road 242, Suzhou, Jiangsu, China
Yaozeng Xu Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China
Shujun Lv Department of Orthopedics, Hai'an People's Hospital, Zhongba Road 17, Hai'an, Jiangsu, China.
Lixin Huang Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China.
Wei Huang Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Lujiang Road 17, Hefei, An'hui, China.
Dechun Geng Department of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, Jiangsu, China.

Collapse

Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research. Sci Rep 2021;11:12451. [PMID: 34127759 PMCID: PMC8203623 DOI: 10.1038/s41598-021-91914-9] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2020] [Accepted: 05/24/2021] [Indexed: 01/23/2023] Open

Poutoglidou F, Pourzitaki C, Manthou ME, Samoladas E, Saitis A, Malliou F, Kouvelas D. Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model. Inflammopharmacology 2021;29:661-672. [PMID: 33982199 DOI: 10.1007/s10787-021-00815-w] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/01/2021] [Accepted: 04/24/2021] [Indexed: 11/24/2022]

Moqbel SAA, Xu K, Chen Z, Xu L, He Y, Wu Z, Ma C, Ran J, Wu L, Xiong Y. Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways. Front Cell Dev Biol 2020;8:568894. [PMID: 33195199 PMCID: PMC7642480 DOI: 10.3389/fcell.2020.568894] [Citation(s) in RCA: 30] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2020] [Accepted: 09/24/2020] [Indexed: 12/31/2022] Open

Connizzo BK, Grodzinsky AJ. Lose-Dose Administration of Dexamethasone Is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. J Orthop Res 2020;38:139-149. [PMID: 31441099 PMCID: PMC7268908 DOI: 10.1002/jor.24451] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/03/2019] [Accepted: 08/13/2019] [Indexed: 02/04/2023]

Tang C, Chen Y, Huang J, Zhao K, Chen X, Yin Z, Heng BC, Chen W, Shen W. The roles of inflammatory mediators and immunocytes in tendinopathy. J Orthop Translat 2018;14:23-33. [PMID: 30035030 PMCID: PMC6034108 DOI: 10.1016/j.jot.2018.03.003] [Citation(s) in RCA: 58] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/18/2017] [Revised: 03/13/2018] [Accepted: 03/19/2018] [Indexed: 02/06/2023] Open

Affiliation(s)

Chenqi Tang Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, China.,Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Orthopaedics Research Institute, Zhejiang Univerisity, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China.,China Orthopaedic Regenerative Medicine (CORMed), Chinese Medical Association, Hangzhou, China
Yangwu Chen Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, China.,Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Orthopaedics Research Institute, Zhejiang Univerisity, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China.,China Orthopaedic Regenerative Medicine (CORMed), Chinese Medical Association, Hangzhou, China
Jiayun Huang Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, China.,Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Orthopaedics Research Institute, Zhejiang Univerisity, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China.,China Orthopaedic Regenerative Medicine (CORMed), Chinese Medical Association, Hangzhou, China
Kun Zhao Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China.,China Orthopaedic Regenerative Medicine (CORMed), Chinese Medical Association, Hangzhou, China
Xiao Chen Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China.,China Orthopaedic Regenerative Medicine (CORMed), Chinese Medical Association, Hangzhou, China
Zi Yin Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China
Boon Chin Heng Faculty of Dentistry, Department of Endodontology, The University of Hong Kong, Pokfulam, Hong Kong
Weishan Chen Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, China.,Orthopaedics Research Institute, Zhejiang Univerisity, Zhejiang 310000, China
Weiliang Shen Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, China.,Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Zhejiang 310000, China.,Orthopaedics Research Institute, Zhejiang Univerisity, Zhejiang 310000, China.,Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China.,China Orthopaedic Regenerative Medicine (CORMed), Chinese Medical Association, Hangzhou, China

Collapse

Wang X, Tang D, Shen P, Xu H, Qiu H, Wu T, Gao X. Analysis of DNA methylation in chondrocytes in rats with knee osteoarthritis. BMC Musculoskelet Disord 2017;18:377. [PMID: 28859619 PMCID: PMC5579940 DOI: 10.1186/s12891-017-1739-2] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/04/2017] [Accepted: 08/25/2017] [Indexed: 12/20/2022] Open

Fu D, Shang X, Ni Z, Shi G. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. Exp Ther Med 2016;12:2735-2740. [PMID: 27703516 DOI: 10.3892/etm.2016.3642] [Citation(s) in RCA: 41] [Impact Index Per Article: 4.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2015] [Accepted: 07/05/2016] [Indexed: 12/18/2022] Open

Influence of Ageing on Tendon Homeostasis. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2016;920:247-60. [DOI: 10.1007/978-3-319-33943-6_24] [Citation(s) in RCA: 23] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/23/2022]

Wu M, Gu Z, Xiao J, Feng J. Differential Expression of Apoptosis-Associated Proteins in Chondrocytes of the Mandibular Condyles of Rabbits with Anterior Disk Displacement. Cranio 2014;26:144-9. [DOI: 10.1179/crn.2008.019] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/31/2022]

Liang JI, Lin PC, Chen MY, Hsieh TH, Chen JJJ, Yeh ML. The effect of tenocyte/hyaluronic acid therapy on the early recovery of healing Achilles tendon in rats. JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE 2014;25:217-227. [PMID: 24072390 DOI: 10.1007/s10856-013-5036-9] [Citation(s) in RCA: 20] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/31/2013] [Accepted: 08/23/2013] [Indexed: 06/02/2023]

Backman LJ, Eriksson DE, Danielson P. Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation. Br J Sports Med 2013;48:1414-20. [PMID: 23996004 PMCID: PMC4173875 DOI: 10.1136/bjsports-2013-092438] [Citation(s) in RCA: 25] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/26/2022]

Gaida JE, Bagge J, Purdam C, Cook J, Alfredson H, Forsgren S. Evidence of the TNF-a System in the Human Achilles Tendon: Expression of TNF-a and TNF Receptor at both Protein and mRNA Levels in the Tenocytes. Cells Tissues Organs 2012;196:339-52. [DOI: 10.1159/000335475] [Citation(s) in RCA: 36] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/28/2011] [Indexed: 12/22/2022] Open

Fini M, Bondioli E, Castagna A, Torricelli P, Giavaresi G, Rotini R, Marinelli A, Guerra E, Orlandi C, Carboni A, Aiti A, Benedettini E, Giardino R, Melandri D. Decellularized human dermis to treat massive rotator cuff tears: in vitro evaluations. Connect Tissue Res 2011;53:298-306. [PMID: 22172074 DOI: 10.3109/03008207.2011.649929] [Citation(s) in RCA: 20] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/03/2023]

Yao L, Bestwick C, Bestwick L, Aspden R, Maffulli N. Non-immortalized human tenocyte cultures as a vehicle for understanding cellular aspects to tendinopathy. Transl Med UniSa 2011;1:173-94. [PMID: 23905032 PMCID: PMC3728842] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/03/2022] Open

Schulze-Tanzil G, Al-Sadi O, Wiegand E, Ertel W, Busch C, Kohl B, Pufe T. The role of pro-inflammatory and immunoregulatory cytokines in tendon healing and rupture: new insights. Scand J Med Sci Sports 2011;21:337-51. [PMID: 21210861 DOI: 10.1111/j.1600-0838.2010.01265.x] [Citation(s) in RCA: 112] [Impact Index Per Article: 8.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/05/2023]

Imirzalioğlu P, Uçkan S, Güler N, Haberal A, Uçkan D. Synovial apoptosis in temporomandibular joint disc displacement without reduction. ACTA ACUST UNITED AC 2009;108:693-8. [PMID: 19716717 DOI: 10.1016/j.tripleo.2009.05.030] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2008] [Revised: 05/05/2009] [Accepted: 05/21/2009] [Indexed: 10/20/2022]

Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GAC. Cytokines and apoptosis in supraspinatus tendinopathy. ACTA ACUST UNITED AC 2009;91:417-24. [DOI: 10.1302/0301-620x.91b3.21652] [Citation(s) in RCA: 144] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/29/2023]

Scutt N, Rolf CG, Scutt A. Tissue specific characteristics of cells isolated from human and rat tendons and ligaments. J Orthop Surg Res 2008;3:32. [PMID: 18652675 PMCID: PMC2515295 DOI: 10.1186/1749-799x-3-32] [Citation(s) in RCA: 17] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/31/2007] [Accepted: 07/24/2008] [Indexed: 12/19/2022] Open

Abstract

Background

Tendon and ligament injuries are common and costly in terms of surgery and rehabilitation. This might be improved by using tissue engineered constructs to accelerate the repair process; a method used successfully for skin wound healing and cartilage repair. Progress in this field has however been limited; possibly due to an over-simplistic choice of donor cell. For tissue engineering purposes it is often assumed that all tendon and ligament cells are similar despite their differing roles and biomechanics. To clarify this, we have characterised cells from various tendons and ligaments of human and rat origin in terms of proliferation, response to dexamethasone and cell surface marker expression.

Methods

Cells isolated from tendons by collagenase digestion were plated out in DMEM containing 10% fetal calf serum, penicillin/streptomycin and ultraglutamine. Cell number and collagen accumulation were by determined methylene blue and Sirius red staining respectively. Expression of cell surface markers was established by flow cytometry.

Results

In the CFU-f assay, human PT-derived cells produced more and bigger colonies suggesting the presence of more progenitor cells with a higher proliferative capacity. Dexamethasone had no effect on colony number in ACL or PT cells but 10 nM dexamethasone increased colony size in ACL cultures whereas higher concentrations decreased colony size in both ACL and PT cultures. In secondary subcultures, dexamethasone had no significant effect on PT cultures whereas a stimulation was seen at low concentrations in the ACL cultures and an inhibition at higher concentrations. Collagen accumulation was inhibited with increasing doses in both ACL and PT cultures. This differential response was also seen in rat-derived cells with similar differences being seen between Achilles, Patellar and tail tendon cells. Cell surface marker expression was also source dependent; CD90 was expressed at higher levels by PT cells and in both humans and rats whereas D7fib was expressed at lower levels by PT cells in humans.

Conclusion

These data show that tendon & ligament cells from different sources possess intrinsic differences in terms of their growth, dexamethasone responsiveness and cell surface marker expression. This suggests that for tissue engineering purposes the cell source must be carefully considered to maximise their efficacy.

Collapse

Gyger O, Botteron C, Doherr M, Zurbriggen A, Schawalder P, Spreng D. Detection and distribution of apoptotic cell death in normal and diseased canine cranial cruciate ligaments. Vet J 2007;174:371-7. [PMID: 16956780 DOI: 10.1016/j.tvjl.2006.07.006] [Citation(s) in RCA: 13] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/23/2005] [Revised: 06/15/2006] [Accepted: 07/03/2006] [Indexed: 11/24/2022]

Fini M, Torricelli P, Giavaresi G, Rotini R, Castagna A, Giardino R. In vitro study comparing two collageneous membranes in view of their clinical application for rotator cuff tendon regeneration. J Orthop Res 2007;25:98-107. [PMID: 17054111 DOI: 10.1002/jor.20295] [Citation(s) in RCA: 40] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/04/2023]

Sharma P, Maffulli N. Basic biology of tendon injury and healing. Surgeon 2005;3:309-16. [PMID: 16245649 DOI: 10.1016/s1479-666x(05)80109-x] [Citation(s) in RCA: 121] [Impact Index Per Article: 6.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/10/2023]

Imirzalioĝlu P, Uckan S, Alaaddinoĝlu EE, Haberal A, Uckan D. Cigarette smoking and apoptosis. J Periodontol 2005;76:737-9. [PMID: 15898934 DOI: 10.1902/jop.2005.76.5.737] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]

Hosaka Y, Teraoka H, Yamamoto E, Ueda H, Takehana K. Mechanism of cell death in inflamed superficial digital flexor tendon in the horse. J Comp Pathol 2005;132:51-8. [PMID: 15629479 DOI: 10.1016/j.jcpa.2004.06.006] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/21/2003] [Accepted: 06/15/2004] [Indexed: 12/21/2022]

Bühling F, Wille A, Röcken C, Wiesner O, Baier A, Meinecke I, Welte T, Pap T. Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis. Respir Res 2005;6:37. [PMID: 15833141 PMCID: PMC1087885 DOI: 10.1186/1465-9921-6-37] [Citation(s) in RCA: 55] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/01/2004] [Accepted: 04/17/2005] [Indexed: 11/10/2022] Open

Bestwick CS, Maffulli N. Reactive oxygen species and tendinopathy: do they matter? Br J Sports Med 2005;38:672-4. [PMID: 15562157 PMCID: PMC1724959 DOI: 10.1136/bjsm.2004.012351] [Citation(s) in RCA: 43] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022]

Sharma P, Maffulli N. Tendon injury and tendinopathy: healing and repair. J Bone Joint Surg Am 2005;87:187-202. [PMID: 15634833 DOI: 10.2106/jbjs.d.01850] [Citation(s) in RCA: 505] [Impact Index Per Article: 25.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/06/2023]

Yue SQ, Yang YL, Zhou JS, Li KZ, Dou KF. Relationship between urokinase-type plasminogen activator receptor and vascular endothelial growth factor expression and metastasis of gallbladder cancer. World J Gastroenterol 2004;10:2750-2. [PMID: 15309734 PMCID: PMC4572208 DOI: 10.3748/wjg.v10.i18.2750] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/15/2022] Open