|
1
|
Hawkins N, Mushaya C. Dedifferentiated liposarcoma of transverse colon: a case report and review of the literature. J Surg Case Rep 2025; 2025:rjaf097. [PMID: 40051808 PMCID: PMC11881694 DOI: 10.1093/jscr/rjaf097] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/13/2024] [Accepted: 02/01/2025] [Indexed: 03/09/2025] Open
Abstract
Dedifferentiated liposarcoma (DDL) is an aggressive subtype of liposarcoma that rarely arises within the abdominal cavity. We describe the case of a 71-year-old female incidental transverse colon mass suspicious for colorectal cancer. Pre-operative biopsy at colonoscopy was not possible due to the lesion's extraluminal location; however, complete resection was achieved through left hemicolectomy. Histology confirmed DDL. Review of the literature found four additional cases of DDL in the transverse colon. Clinical presentation, management, and follow-up were reviewed, illustrating poor outcomes; three of the five cases died within 3 years of surgery. DDL is associated with higher rates of local recurrence, metastasis, and mortality compared to well-differentiated liposarcomas. While limited by its rarity, DDL in the transverse colon appears to follow similarly poor outcomes.
Collapse
Affiliation(s)
- Nicole Hawkins
- Department of Colorectal Surgery, Townsville University Hospital, 100 Angus Smith Dr, Douglas QLD 4814, Australia
| | - Chrispen Mushaya
- Department of Colorectal Surgery, Townsville University Hospital, 100 Angus Smith Dr, Douglas QLD 4814, Australia
| |
Collapse
|
|
2
|
Vishnu J, Kapil N, Pe V, Patnaik P. Giant Colonic Lipoma Remains a Surgeon's Domain: A Report of Two Cases. Cureus 2023; 15:e43488. [PMID: 37719513 PMCID: PMC10499540 DOI: 10.7759/cureus.43488] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 08/13/2023] [Indexed: 09/19/2023] Open
Abstract
Colonic lipomas are rare benign submucosal tumors that are mostly asymptomatic. With increasing size, they may develop symptoms and complications. The acute presentation may be intestinal obstruction secondary to intussusception or gastrointestinal bleeding. The chronic presentation may be subtle and mimic a colonic malignancy. Symptoms include altered bowel habits, abdominal pain, lower gastrointestinal bleeding, and weight loss. Diagnostic evaluation includes advanced imaging such as Computed Tomography, Magnetic Resonance Imaging, and Endoscopy. With the advent of endoscopic submucosal dissection techniques, the therapeutic capabilities of endoscopy have expanded over the decade. However, surgical interventions were reserved for large, symptomatic lipomas, and resection varies from segmental colonic resection to hemicolectomy. Size and clinical presentation determine the therapeutic approach. We, with this, report two cases of giant colonic lipoma in the right colon causing a colo-colic intussusception.
Collapse
Affiliation(s)
- Jaai Vishnu
- General Surgery, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, IND
| | - Nagaraj Kapil
- Surgical Gastroenterology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, IND
| | - Vaishnavi Pe
- General Surgery, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, IND
| | - Pooja Patnaik
- General Surgery, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, IND
| |
Collapse
|
|
3
|
Fujii K, Okita A, Tsukuda K, Yamamoto S, Yokoyama N. Totally laparoscopic colectomy with intracorporeal anastomosis for colonic liposarcoma: A case report. Asian J Endosc Surg 2022; 15:824-827. [PMID: 35595263 DOI: 10.1111/ases.13077] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/01/2022] [Revised: 04/24/2022] [Accepted: 04/29/2022] [Indexed: 11/30/2022]
Abstract
Liposarcoma is a type of soft tissue sarcoma. Primary colonic liposarcomas are extremely rare. An 86-year-old man with diarrhea and anorexia visited our outpatient clinic at Okayama City Hospital. Colonoscopy and computed tomography imaging revealed a large submucosal tumor in the descending colon with a maximum diameter of approximately 10 cm. He underwent totally laparoscopic left hemicolectomy with intracorporeal anastomosis. The histopathological diagnosis was a well-differentiated liposarcoma without lymph node metastases. The patient's postoperative course was uneventful. We herein report a rare case of totally laparoscopic colectomy with intracorporeal anastomosis in an elderly patient with colonic liposarcoma.
Collapse
Affiliation(s)
- Kento Fujii
- Department of Surgery, Okayama City Hospital, Okayama, Japan
| | - Atsushi Okita
- Department of Surgery, Okayama City Hospital, Okayama, Japan
| | | | | | - Nobuji Yokoyama
- Department of Surgery, Okayama City Hospital, Okayama, Japan
| |
Collapse
|
|
4
|
Héroin L, Lafeuille P, Lambin T, Mayer P, Bordet M, Rostain F, Pioche M. Endoscopic submucosal dissection of a small rectal submucosal lesion: a rare case of rectal liposarcoma. Endoscopy 2022; 54:E504-E505. [PMID: 34655058 DOI: 10.1055/a-1645-1282] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/10/2022]
Affiliation(s)
- Lucile Héroin
- Gastroenterology and Hepatology Unit, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
| | - Pierre Lafeuille
- Department of Endoscopy and Hepatogastroenterology, Pavillon L, Edouard Herriot Hospital, Lyon, France
| | - Thomas Lambin
- Department of Endoscopy and Hepatogastroenterology, Pavillon L, Edouard Herriot Hospital, Lyon, France
| | - Pierre Mayer
- Gastroenterology and Hepatology Unit, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
| | - Martin Bordet
- Department of Gastroenterology, University Hospital of Rennes, Pontchaillou, Rennes, France
| | - Florian Rostain
- Department of Endoscopy and Hepatogastroenterology, Pavillon L, Edouard Herriot Hospital, Lyon, France
| | - Mathieu Pioche
- Department of Endoscopy and Hepatogastroenterology, Pavillon L, Edouard Herriot Hospital, Lyon, France
| |
Collapse
|
|
5
|
Cho JH, Byeon JH, Lee SH. Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report. World J Gastroenterol 2022; 28:2625-2632. [PMID: 35949354 PMCID: PMC9254141 DOI: 10.3748/wjg.v28.i23.2625] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/18/2021] [Revised: 01/29/2022] [Accepted: 05/07/2022] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Liposarcoma is one of the most common adult mesenchymal tumors but is uncommon in the gastrointestinal tract and extremely rare in the stomach. Furthermore, the histological subtypes of liposarcoma usually reported in the stomach are well-differentiated or myxoid, and few reports have been issued on small-sized gastric liposarcomas resected endoscopically and followed up. Herein, we report a case of primary gastric dedifferentiated liposarcoma (DL) that was resected endoscopically.
CASE SUMMARY A 67-year-old female Korean patient was referred to our institution for further evaluation of a gastric submucosal tumor (SMT) located in the lesser curvature of the gastric body by esophagogastroduodenoscopy. Endoscopic ultrasound revealed a well-circumscribed, slightly heterogeneous, isoechoic, 17 mm × 10 mm sized mass originating from the third sonographic layer. Computed tomography showed no evidence of significant lymph node enlargement or distant metastasis. Endoscopic resection was undertaken using the snare resection technique after mucosal precutting to provide a definitive histopathologic diagnosis, which proved to be consistent with DL, based on its morphology and the immunoexpressions of MDM2 and CDK4. The patient was planned for surgery because the deep resection margin was positive for malignancy. After declining any invasive procedure or adjuvant treatment, the patient was placed under close follow-up, and at one year after endoscopic resection, remained disease free.
CONCLUSION This is the first reported case of a small primary gastric DL resected endoscopically and followed up. This report demonstrates that when diagnosis of a SMT is uncertain, the use of invasive techniques, including endoscopic resection, should be considered.
Collapse
Affiliation(s)
- Joon Hyun Cho
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, South Korea
| | - Jun Hyeon Byeon
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, South Korea
| | - Si Hyung Lee
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, South Korea
| |
Collapse
|
|
6
|
Kim MC, Park SS, Sohn DK, Han KS, Park SY, Chang HJ. Pedunculated colonic liposarcoma of the ileocecal valve manifesting as intussusception: A case report and literature review. J Dig Dis 2021; 22:672-677. [PMID: 34612002 DOI: 10.1111/1751-2980.13057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/28/2021] [Revised: 08/19/2021] [Accepted: 10/04/2021] [Indexed: 12/11/2022]
Affiliation(s)
- Min Chul Kim
- Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, South Korea
| | - Sung Sil Park
- Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, South Korea
| | - Dae Kyung Sohn
- Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, South Korea
| | - Kyung Su Han
- Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, South Korea
| | - Seog Yun Park
- Department of Pathology, Research Institute and Hospital, National Cancer Center, Goyang, Korea
| | - Hee Jin Chang
- Department of Pathology, Research Institute and Hospital, National Cancer Center, Goyang, Korea
| |
Collapse
|
|
7
|
Serafini L, Lauro A, Eusebi LH, Vaccari S, Pirini MG, D'Andrea V, Marino IR, Cervellera M, Tonini V. Dedifferentiated Liposarcoma of the Descending Colon: A Case Report and Review of the Literature. Dig Dis Sci 2020; 65:1643-1651. [PMID: 32300935 DOI: 10.1007/s10620-020-06254-x] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/06/2023]
Abstract
Dedifferentiated liposarcomas are rare; localization of these tumors in the descending colon is extremely uncommon. We describe the case of a 75-year-old man with a dedifferentiated liposarcoma originating from the descending colon that manifested as partial bowel obstruction. The very uncommon presentation of this rare disease contributed to a challenging diagnostic process. The patient was successfully treated by surgical resection of the mass through left hemicolectomy. Although exceptionally unusual, soft tissue sarcomas should be considered in the differential diagnosis for bowel obstruction. Currently, radical resection of the mass is considered to be the first-line treatment.
Collapse
Affiliation(s)
- L Serafini
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy
| | - A Lauro
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy.
| | - L H Eusebi
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy
| | - S Vaccari
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy
| | - M G Pirini
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy
| | - V D'Andrea
- Department of Surgical Sciences, La Sapienza University, Umberto I Hospital, Rome, Italy
| | - I R Marino
- Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA
| | - M Cervellera
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy
| | - V Tonini
- Emergency Surgery, GI and Pathology Department, St. Orsola University Hospital, Bologna, Italy
| |
Collapse
|
|
8
|
Gajzer DC, Fletcher CD, Agaimy A, Brcic I, Khanlari M, Rosenberg AE. Primary gastrointestinal liposarcoma-a clinicopathological study of 8 cases of a rare entity. Hum Pathol 2020; 97:80-93. [PMID: 31884085 DOI: 10.1016/j.humpath.2019.12.004] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/13/2019] [Revised: 12/15/2019] [Accepted: 12/17/2019] [Indexed: 12/11/2022]
Abstract
Primary gastrointestinal liposarcoma is rare, and information regarding this entity is largely based on single case studies. We report on 8 patients with primary liposarcoma of the gastrointestinal tract and review the pertinent literature. The cohort includes 6 men and 2 women who ranged in age from 51 to 81 years (median 68.5). Two tumors arose in the stomach, 4 in the small intestine, and 2 in the large intestine. Tumors ranged in size from 2.5 to 14.5 cm (median 7 cm), originated in the submucosa or muscularis propria of the intestinal wall, and frequently protruded into the bowel lumen, resulting in mucosal ulceration and luminal obstruction. Six tumors were dedifferentiated liposarcomas, and 2 were well-differentiated liposarcoma. Surgical excision was performed on all tumors except for 1 case of dedifferentiated liposarcoma. On follow-up, 1 patient with dedifferentiated liposarcoma developed a lytic sacral lesion suspicious for metastasis 4 months after resection of the primary, and another underwent marginal resection and presented with recurrence 4 years later, had tumor re-resection, and was considered disease-free at 6 weeks postsurgery. A third patient with dedifferentiated liposarcoma was alive with unknown disease status at 17 months following surgery, and another patient with dedifferentiated liposarcoma was alive without evidence of disease at 30 months following surgery. No follow-up information on the remaining patients is available. Overall, liposarcomas of the intestinal tract are most frequently high-grade dedifferentiated tumors that are biologically aggressive and require surgical excision with widely negative margins to help reduce the risk of local recurrence and dissemination. Important in the differential diagnosis is malignant gastrointestinal stromal tumor. Care must be taken not to misdiagnose one entity for the other because the correct diagnosis carries important therapeutic implications.
Collapse
Affiliation(s)
- David C Gajzer
- Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL
| | - Christopher D Fletcher
- Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
| | - Abbas Agaimy
- Institute of Pathology, University Hospital Erlangen, Germany
| | - Iva Brcic
- Institute of Pathology, Medical University of Graz, Austria
| | - Mahsa Khanlari
- Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL
| | - Andrew E Rosenberg
- Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL.
| |
Collapse
|
|
9
|
Guadagno E, Peltrini R, Stasio L, Fiorentino F, Bucci L, Terracciano L, Insabato L. A challenging diagnosis of mesenchymal neoplasm of the colon: colonic dedifferentiated liposarcoma with lymph node metastases-a case report and review of the literature. Int J Colorectal Dis 2019; 34:1809-1814. [PMID: 31501928 DOI: 10.1007/s00384-019-03394-z] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 09/04/2019] [Indexed: 02/07/2023]
Abstract
PURPOSE We report a case of primitive colonic dedifferentiated liposarcoma along with lymph node metastases. METHODS The patient's clinical, radiologic, surgical, and histologic data were reviewed, as well as the literature on colonic dedifferentiated liposarcoma with a focus on the incidence of lymph node metastasis in gastrointestinal sarcomas and on the differential diagnosis with other spindle cell tumors in the gastrointestinal tract. RESULTS A 53-year-old man was referred to our hospital with a 3 year-history of pain on the right back that was refractory to drugs. He performed an abdominal computed tomography scan which revealed a colonic wall thickening in the hepatic flexure and a few serosal nodularities. With these findings, the patient underwent an extended right hemicolectomy. On histopathologic examination, it turned out to be a colonic dedifferentiated liposarcoma with lymph node metastases. CONCLUSIONS The present case was a challenging diagnosis both at presurgical and histopathological level because it strongly mimicked a colonic adenocarcinoma. This was due to non-specific clinical and radiological presentation, to the non-characteristic histologic morphology and to the misleading presence of lymph node metastases. Malignant stromal tumors of the gastrointestinal tract beyond gist are fairly rare entities. Colonic dedifferentiated liposarcoma must be kept in mind and must be considered in the differential diagnosis of gastrointestinal tumors.
Collapse
Affiliation(s)
- Elia Guadagno
- Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
| | - Roberto Peltrini
- Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy
| | - Loredana Stasio
- Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy
| | | | - Luigi Bucci
- Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy
| | - Luigi Terracciano
- Institute of Pathology, Molecular Pathology Division, University Hospital Basel, Basel, Switzerland
| | - Luigi Insabato
- Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy
| |
Collapse
|
|
10
|
Li CF, Yang XR, Yao J, Huang JJ, Tan N, Zhang SY, Xu GQ, Zheng H. Giant recurrent mixed-type liposarcoma of the retroperitoneum: report of a case and review of literature. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2019; 12:1406-1411. [PMID: 31933956 PMCID: PMC6947073] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Subscribe] [Scholar Register] [Received: 01/21/2019] [Accepted: 02/21/2019] [Indexed: 06/10/2023]
Abstract
Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals, especially tumors of mixed histologic pattern. We present a case of a 63-year-old woman with a history of slowly increasing abdominal volume over 2 years. The diagnosis of giant and multiple retroperitoneal mass suspected of liposarcoma was confirmed by computed tomography. The patient underwent resection of 7 tumor masses together weighing 5 kg. The microscopic diagnosis was mixed-type liposarcoma of the retroperitoneum. 8 months after surgery, the patient suffered multiple metastases in the liver and abdominal wall, and upper digestive tract hemorrhage. Although this type of tumor is rarely seen, tumor tissue should be thoroughly gathered and analyzed on histologic examination to reach final diagnosis. Knowledge of the subtype of liposarcoma is important for proper prognosis and treatment of the patient. To the best of our knowledge, this is the first report of mixed-type retroperitoneal liposarcoma with three components described in the English literature.
Collapse
Affiliation(s)
- Cheng-Fang Li
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Xiao-Rong Yang
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Jin Yao
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Jia-Jia Huang
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Na Tan
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Su-Yuan Zhang
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Gao-Qiang Xu
- Department of Imaging, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| | - Hong Zheng
- Department of Pathology, The Affiliated Hospital of Zunyi Medical UniversityGuizhou 563000, China
| |
Collapse
|
|
11
|
Sultania M, Muduly D, Jha S, Kar M, Mitra S. Primary colonic liposarcomatosis: report of a case with review of literature. AUTOPSY AND CASE REPORTS 2019; 9:e2018056. [PMID: 30863730 PMCID: PMC6394358 DOI: 10.4322/acr.2018.056] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/12/2018] [Accepted: 09/18/2018] [Indexed: 01/16/2023] Open
Abstract
The colon is a rare site of occurrence of liposarcoma, as either the primary site or by secondary involvement from a retroperitoneal liposarcoma. Liposarcomatosis denotes simultaneous occurrence of multiple liposarcomas. There are only 17 cases of primary colonic liposarcoma reported in the English literature-one of which was primary colonic liposarcomatosis. We depict the second case of primary colonic liposarcomatosis in a 57-year-old female who presented with abdominal swelling and pain. On exploratory laparotomy, two large masses were seen arising from the wall of the right colon along with multiple smaller masses attached to the colon. Right hemicolectomy with en bloc excision of the masses was performed along with hysterectomy and pelvic floor repair. Macroscopically, multiple exophytic masses and one endophytic mass were identified. The exophytic masses were of variable size and were found to hang from the colon by a thin pedicle simulating variable-sized appendices epiploicae. Histopathologically, the lesions showed the morphology of well-differentiated liposarcoma. This appears to be a case of primary colonic liposarcomatosis. There is only one other similar case reported in the English literature, to the best of our knowledge.
Collapse
Affiliation(s)
- Mahesh Sultania
- All India Institute of Medical Sciences, Department of Surgical Oncology. Bhubaneswar, Orissa, India
| | - Dillip Muduly
- All India Institute of Medical Sciences, Department of Surgical Oncology. Bhubaneswar, Orissa, India
| | - Shilpy Jha
- All India Institute of Medical Sciences, Department of Pathology and Laboratory Medicine, Bhubaneswar, Orissa, India
| | - Madhabananda Kar
- All India Institute of Medical Sciences, Department of Surgical Oncology. Bhubaneswar, Orissa, India
| | - Suvradeep Mitra
- All India Institute of Medical Sciences, Department of Pathology and Laboratory Medicine, Bhubaneswar, Orissa, India
| |
Collapse
|
|
12
|
Computed tomography identification of an exophytic colonic liposarcoma. Radiol Case Rep 2016; 11:161-4. [PMID: 27594941 PMCID: PMC4996942 DOI: 10.1016/j.radcr.2016.06.005] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/29/2016] [Revised: 06/07/2016] [Accepted: 06/15/2016] [Indexed: 11/20/2022] Open
Abstract
It may be difficult to ascertain the relationship between a large intra-abdominal tumor and the adjacent organs if they are close together. In the current case, a definitive preoperative diagnosis of an exophytic colonic tumor was obtained by the demonstration of obtuse angles between the tumor and colon and by distinct recognition of the mucosa-submucosa of the colonic wall on computed tomography; the accuracy of this preoperative diagnosis was subsequently confirmed by pathologic findings.
Collapse
|
|
13
|
Fernandes SR, Rita Gonçalves A, Lopes J, Moura Santos P, Lopes da Silva H, Crujo C, Velosa J. Primary liposarcoma of the sigmoid presenting as colonic intussusception - A case report. REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 2016; 108:591-4. [DOI: 10.17235/reed.2016.3943/2015] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/20/2022]
|
|
14
|
Xun J, Song X, Gao S, Yang H, Li Z, Li L. Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as risk biomarker for liposarcoma. Mitochondrial DNA A DNA Mapp Seq Anal 2015; 27:3403-4. [PMID: 25812053 DOI: 10.3109/19401736.2015.1018240] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]
Abstract
Single nucleotide polymorphisms (SNPs) in the Displacement-loop (D-loop) region of mitochondrial DNA have been reported to be associated with cancer risk in various types of cancer. To assess the frequency of D-loop SNPs in a large series of liposarcoma and establish correlations with cancer risk, we sequenced the D-loop of 82 liposarcoma patients and analyzed their use as predictive biomarkers for liposarcoma risk. The minor alleles of nucleotides 73G, 523-524del, 16,290T, 16,319A, 16,356C were associated with an increased risk for liposarcoma patients, whereas the insertion of C at the site 315 (located within the D310) were associated with a decreased risk for liposarcoma patients. These results suggest that SNPs in the mitochondrial D-loop should be considered as a biomarker which may be useful for the early detection of liposarcoma in individuals at risk of this cancer.
Collapse
Affiliation(s)
| | | | - Shejun Gao
- b Department of Clinical Laboratory , and
| | - Huichai Yang
- c Department of Pathology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , P.R. China
| | | | | |
Collapse
|
|
15
|
Peduncular Liposarcoma of the Colon: a Case Report and Literature Review. J Gastrointest Cancer 2014; 45 Suppl 1:248-51. [PMID: 25216753 DOI: 10.1007/s12029-014-9647-2] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2022]
|
|
16
|
Tsuruta A, Notohara K, Park T, Itoh T. Dedifferentiated liposarcoma of the rectum: A case report. World J Gastroenterol 2012; 18:5979-81. [PMID: 23139616 PMCID: PMC3491607 DOI: 10.3748/wjg.v18.i41.5979] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/29/2012] [Revised: 07/31/2012] [Accepted: 08/03/2012] [Indexed: 02/06/2023] Open
Abstract
Liposarcoma is one of the most common soft tissue sarcomas found in adults, and it usually occurs in the retroperitoneum and the extremities. Here, we describe a case of dedifferentiated liposarcoma originating from a well-differentiated liposarcoma of the mesorectum that presented as a protruding mass in the rectal lumen. Hartmann’s operation with total mesorectal excision was performed and the tumor was removed radically. No management guidelines are currently available for liposarcoma of the rectum. We propose that complete surgical resection be required for the treatment of rectal liposarcoma and that a long-term detailed follow up is necessary.
Collapse
|
|
17
|
Cha EJ. Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass. World J Gastrointest Oncol 2011; 3:116-8. [PMID: 21860688 PMCID: PMC3158862 DOI: 10.4251/wjgo.v3.i7.116] [Citation(s) in RCA: 13] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/14/2011] [Revised: 06/20/2011] [Accepted: 06/27/2011] [Indexed: 02/05/2023] Open
Abstract
Dedifferentiated liposarcoma (DDLPS) is a variant of liposarcoma but with a more aggressive course. It occurs most commonly in the retroperitoneum and rarely in any other anatomical location. We describe a case of DDLPS arising from the small bowel mesentery presenting as submucosal mass of the small bowel. The current case is unusual as the tumor originated from the small bowel mesentery and a dedifferentiated component transmurally invaded the small bowel wall, including the small bowel submucosa.
Collapse
Affiliation(s)
- Eun-Jung Cha
- Eun-Jung Cha, Department of Pathology, Konyang University Hospital, Konyang University School of Medicine, Daejeon 302-718, South Korea
| |
Collapse
|
|
18
|
Choi YY, Kim YJ, Jin SY. Primary liposarcoma of the ascending colon: a rare case of mixed type presenting as hemoperitoneum combined with other type of retroperitoneal liposarcoma. BMC Cancer 2010; 10:239. [PMID: 20507577 PMCID: PMC2887402 DOI: 10.1186/1471-2407-10-239] [Citation(s) in RCA: 23] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2009] [Accepted: 05/27/2010] [Indexed: 12/18/2022] Open
Abstract
BACKGROUND Liposarcoma occurs most commonly in the extremities and retroperitoneum, however, it has been rarely observed in the colon. CASE PRESENTATION A case is reported a 41-year-old man with liposarcoma of ascending colon which was presented as hemoperitoneum and combined with a different histological type of retroperitoneal liposarcoma. He visited hospital with right lower abdominal pain and palpable mass. Laboratory data including tumor markers were within normal limits, and computed tomography revealed a 15 x 10 cm sized enhancing soft mass. Right hemicolectomy was performed, and after that, a further large retroperitoneal mass was revealed and this was also radically excised. Mixed-type colon liposarcoma and well differentiated type of retroperitoneal liposarcoma were diagnosed in pathologic report. The patient has remained free of disease for 24 months. CONCLUSIONS No standardized guidelines have been established for its treatment because too small a number of cases have been reported, but surgical resection was considered the treatment of choice.
Collapse
Affiliation(s)
- Yoon Young Choi
- Department of Surgery, Soonchunhyang University College of Medicine, Seoul, Korea
| | | | | |
Collapse
|