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Geetha SD, Kavoussi L, Thomas R, Savant D. Primary Retroperitoneal Mucinous Cystadenocarcinoma: A Case Report. Cureus 2023; 15:e39983. [PMID: 37415996 PMCID: PMC10321359 DOI: 10.7759/cureus.39983] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/04/2023] [Indexed: 07/08/2023] Open
Abstract
Mucinous neoplasms are commonly seen in the ovaries and pancreas. Their occurrence in the retroperitoneum is uncommon. We present a case of a retroperitoneal mucinous cystadenocarcinoma in a 54-year-old female who presented with right flank pain. Imaging demonstrated an 8.6 × 7.9 cm mass at the anterior surface of the lower pole of the right kidney, suspicious for renal cell carcinoma. Serum tumor markers carbohydrate antigen 19-9 (CA 19-9) and cancer embryonic antigen (CEA) were within normal limits, and cancer antigen 125 (CA 125) was elevated. Surgical resection of the mass was performed. Intraoperatively, the mass was noted to lie in the retroperitoneum, unattached to the kidney. On gross examination, a 10.0 × 7.0 × 7.0 cm unilocular cystic structure with red-brown mucoid material was present. The inner lining was mostly smooth with areas of excrescences, covering less than 5% of the surface area. Microscopic examination showed cystic areas lined by mucinous epithelium with an underlying ovarian-type stroma. Solid areas showed features of a borderline papillary mucinous tumor with invasive carcinoma. A diagnosis of mucinous cystadenocarcinoma was made. Their occurrence in the retroperitoneum is unusual. Although rare, this entity should always be considered in the differential diagnosis of retroperitoneal cystic lesions.
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2
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Zhang Y, Yang J, Chen Z, Sun J, Wang P. Laparoscopic Resection and Pre-Operative Imaging of Primary Retroperitoneal Mucinous Neoplasms: A Retrospective Case Series. Cancer Manag Res 2020; 12:5451-5460. [PMID: 32753962 PMCID: PMC7351976 DOI: 10.2147/cmar.s254197] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/16/2020] [Accepted: 06/11/2020] [Indexed: 11/23/2022] Open
Abstract
Purpose The purpose of this paper is to present the clinicopathological features of primary retroperitoneal mucinous neoplasms (PRMNs), to evaluate the diagnostic role of pre-operative radiological examinations, and to determine the feasibility of total resection using the laparoscopic approach. Methods We retrospectively analysed the clinicopathological and radiological features of 10 PRMN cases who underwent surgical resection from January 2000 to December 2019. Results Ten PRMN cases were evaluated in this study, including 1 malignant case, 4 borderline cases, and 5 benign cases. The most common primary complaints were pain (60%) and palpable mass (60%). Of the 8 cases with pre-operative CT results, 75% of the borderline or malignant cysts and none of the benign cysts were large in size (size>11.6 cm). Half of the non-benign masses and none of the benign ones were lobulated. Thick wall (≥3 mm) and irregular wall were found in 25% and 50% of the non-benign cases, respectively. Wall enhancement was detected in 75% of the non-benign cases and 25% of the benign cases. Enhanced mural nodules were identified in 50% of the non-benign patients. Septa were found in 25% of the non-benign cases. Complete dissection of the tumour without rupture or post-operative complications was achieved laparoscopically in 90% of the cases. All patients were alive with no recurrence at the last follow-up at an average of 28.1±26.6 months. Conclusion Larger size and lobulation of the cyst, presence and contrast enhancement of thick and irregular cyst walls, mural nodules, and internal septa may be imaging features suggestive of malignancy. Complete resection of PRMN through the laparoscopic approach is feasible in experienced institutions.
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Affiliation(s)
- Yuyang Zhang
- Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China
| | - Jiejin Yang
- Department of Radiology, Peking University First Hospital, Peking University, Beijing, People's Republic of China
| | - Zeyang Chen
- Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China
| | - Jiali Sun
- Department of Radiology, Peking University First Hospital, Peking University, Beijing, People's Republic of China
| | - Pengyuan Wang
- Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China
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Tomisaki I, Matsuyama A, Jotatsu M, Yamamura S, Onishi R, Fujimoto N. Primary retroperitoneal mucinous cystadenocarcinoma with transition from the mesothelium. IJU Case Rep 2020; 3:137-140. [PMID: 33392473 PMCID: PMC7770595 DOI: 10.1002/iju5.12169] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/26/2020] [Revised: 04/29/2020] [Accepted: 04/30/2020] [Indexed: 11/15/2022] Open
Abstract
INTRODUCTION Mucinous cystic neoplasms are uncommon among the tumors that develop in the retroperitoneum. We report a case of primary retroperitoneal mucinous cystadenocarcinoma with pathological considerations. CASE PRESENTATION A 47-year-old woman complaining of abdominal discomfort presented at our hospital. Abdominal computed tomography and magnetic resonance imaging showed a large cystic tumor with small solid nodules located in the right retroperitoneum. The tumor was completely removed and the microscopic findings were consistent with primary retroperitoneal mucinous cystadenocarcinoma. Two years after the surgery, the patient is alive without recurrence of the tumor. CONCLUSION The microscopic findings suggested that the primary retroperitoneal mucinous cystadenocarcinoma developed from the metaplasia of the remnant coelomic epithelium. A complete tumor resection that includes the adjacent peritoneum is important to prevent local recurrence.
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Affiliation(s)
- Ikko Tomisaki
- Department ofUrologySchool of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuokaJapan
| | - Atsuji Matsuyama
- Department ofPathology and OncologySchool of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuokaJapan
| | - Mao Jotatsu
- Department ofPathology and OncologySchool of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuokaJapan
| | - Sohei Yamamura
- Department ofUrologySchool of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuokaJapan
| | - Rei Onishi
- Department ofUrologySchool of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuokaJapan
| | - Naohiro Fujimoto
- Department ofUrologySchool of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuokaJapan
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4
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Chae YK, Saleem N, Roh Y, Bilal H, Viveiros P, Sukhadia B, Lin X, Sheikh MM, Park LC. Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: a case report and literature review. BMC Cancer 2019; 19:748. [PMID: 31362708 PMCID: PMC6668104 DOI: 10.1186/s12885-019-5934-4] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/25/2018] [Accepted: 07/12/2019] [Indexed: 11/16/2022] Open
Abstract
Background Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment. Case presentation We describe a unique case of PRSA in a 71-year-old male who presented with right-sided lower back pain and numbness. Magnetic resonance imaging identified a mass invading the adjacent psoas muscle and twelfth rib. Tissue biopsy confirmed poorly differentiated PRSA. Patient was initially treated with neoadjuvant carboplatin and paclitaxel chemotherapy regimen. This resulted in complete radiological resolution of the tumor. However, 12 weeks later, rapid recurrence was noted on follow-up CT scan. The patient was then treated with external radiotherapy with concurrent nivolumab, an anti-PD-1 antibody. The patient displayed a positive response to treatment with reduction in primary tumor and metastases and had a sustained disease control. Conclusion Treatment with radiotherapy in combination with anti-PD-1 antibody could be an effective modality of management for PRSA. Electronic supplementary material The online version of this article (10.1186/s12885-019-5934-4) contains supplementary material, which is available to authorized users.
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Affiliation(s)
- Young Kwang Chae
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA.
| | - Naira Saleem
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
| | - Yoonhwan Roh
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
| | - Haris Bilal
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
| | - Pedro Viveiros
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
| | - Bhoomika Sukhadia
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
| | - Xiaoqi Lin
- Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
| | - Muhammad Mubbashir Sheikh
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
| | - Lee Chun Park
- Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL- 60611, USA
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Pesapane F, Van Renterghem S, Patella F, De Visschere P, Villeirs G. A case report and a literature review of primary retroperitoneal mucinous cystadenoma: the importance of imaging in diagnosis and management. Future Oncol 2018; 14:2923-2931. [DOI: 10.2217/fon-2017-0649] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/19/2023] Open
Abstract
Primary retroperitoneal mucinous cystadenoma (PRMC) is an extremely rare tumor: its histogenesis and its biological behavior remain speculative. Since most retroperitoneal tumors are malignant, a preoperative diagnosis of benignity is essential and it can be reached through imaging examinations, allowing a conservative management approach. We describe the case of a 52-year-old woman with abdominal pain and a palpable mass. Computed tomography of the abdomen revealed a retroperitoneal cystic mass, which was resected successfully through laparoscopy and diagnosed as PRMC. Although there are no pathognomonic, clinical or radiological findings for PRMC, it should be included in the list of differential diagnoses and its imaging criteria of benignity should always be sought, with the aim to exclude malignant tumors.
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Affiliation(s)
- Filippo Pesapane
- Department of Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
- Postgraduation School in Radiodiagnostics, Università degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milano, MI, Italy
| | - Sofie Van Renterghem
- Department of Pathology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
| | - Francesca Patella
- Postgraduation School in Radiodiagnostics, Università degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milano, MI, Italy
| | - Pieter De Visschere
- Department of Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
| | - Geert Villeirs
- Department of Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
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Tokai H, Nagata Y, Taniguchi K, Matsumura N, Kitasato A, Tokunaga T, Takeshita H, Kuroki T, Maeda S, Ito M, Fujioka H. The long-term survival in primary retroperitoneal mucinous cystadenocarcinoma: a case report. Surg Case Rep 2017; 3:117. [PMID: 29177806 PMCID: PMC5702287 DOI: 10.1186/s40792-017-0394-z] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2017] [Accepted: 11/15/2017] [Indexed: 12/16/2022] Open
Abstract
Background Primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is extremely rare, and its biological behavior, pathogenesis, optimum treatments, and prognosis remain to be elucidated. We herein report a case of PRMC with an 80-month follow-up. Case presentation A 29-year-old woman was diagnosed with unknown retroperitoneal tumor with benign right ovarian cyst and uterine fibroids, and she underwent laparotomy. The tumor was completely resected with a subsequent histopathological diagnosis of primary retroperitoneal mucinous cystadenocarcinoma (PRMC). Eighty months after surgery, she remains recurrence-free. Conclusion PRMC is an extremely rare tumor. Only around 60 cases have so far been published in the literature. The preoperative diagnosis of PRMC is difficult, and a definitive diagnosis can usually only be made based on the findings of histopathological examinations after surgery. Presently, only radical resection is useful for both diagnostic and therapeutic purposes. The optimal long-term management after surgery is still not well established. Further studies on PRMC are therefore needed to elucidate the etiology and establish effective treatments.
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Affiliation(s)
- Hirotaka Tokai
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan.
| | - Yasuhiro Nagata
- Center for Comprehensive Community Care Education Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
| | - Ken Taniguchi
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Naomi Matsumura
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Amane Kitasato
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Takayuki Tokunaga
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Hiroaki Takeshita
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Tamotsu Kuroki
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Shigeto Maeda
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Masahiro Ito
- Department of pathology, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
| | - Hikaru Fujioka
- Department of Surgery, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, 856-8562, Japan
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Mori A, Changela K, Alhankawi D, Itskovich A, Butt A, Reddy M. A Giant Primary Retroperitoneal Serous Cystadenoma: Case Report and Review of Retroperitoneal Cysts. Surg J (N Y) 2017; 3:e32-e37. [PMID: 28825017 PMCID: PMC5553492 DOI: 10.1055/s-0037-1599820] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/19/2016] [Accepted: 01/30/2017] [Indexed: 11/25/2022] Open
Abstract
Primary retroperitoneal serous cystadenomas (PRSCs) are rare cystic lesions whose pathogenesis is currently not well understood. Although the vast majority of tumors are benign, early recognition and resection is necessary to avoid malignant transformation, rupture, and secondary infection. Here we present the case of a 79-year-old woman who presented with confusion, visual hallucinations, and a history of fall. As part of the work-up for abdominal distension, computed tomography scan of the abdomen and pelvis was performed, which revealed a right-sided retroperitoneal cystic lesion measuring 26.6 × 16.7 cm in size. The lesion was resected laparoscopically, and the surgical specimen measured 28 × 17 cm. Histology revealed a serous cystadenoma. The postsurgical course was uneventful, and no radiological recurrence was noted on 3 months follow-up. Very few primary retroperitoneal cystic lesions have been reported in the literature. Most lesions are benign and predominantly occur in females. They may remain asymptomatic for long periods of time and are usually discovered when they reach very large in size. In rare cases, these lesions may have malignant potential. Diagnosis of PRSC should be considered in the differential diagnosis of all retroperitoneal cysts.
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Affiliation(s)
- Amit Mori
- Division of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Clinical Affiliate of Mount Sinai Hospital, Brooklyn, New York
| | - Kinesh Changela
- Division of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Clinical Affiliate of Mount Sinai Hospital, Brooklyn, New York
| | - Dhuha Alhankawi
- Division of Internal Medicine, The Brooklyn Hospital Center, Clinical Affiliate of Mount Sinai Hospital, Brooklyn, New York
| | - Alexander Itskovich
- Division of Surgery, The Brooklyn Hospital Center, Clinical Affiliate of Mount Sinai Hospital, Brooklyn, New York
| | - Ahmar Butt
- Division of Internal Medicine, The Brooklyn Hospital Center, Clinical Affiliate of Mount Sinai Hospital, Brooklyn, New York
| | - Madhavi Reddy
- Division of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Clinical Affiliate of Mount Sinai Hospital, Brooklyn, New York
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9
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Pellegrino B, Sikokis A, Bersanelli M, Leonetti A, Leonardi F, Di Meglio G, Buti S. Primary Retroperitoneal Cystoadenocarcinoma: A Systematic Review. Gynecol Obstet Invest 2016; 81:385-93. [DOI: 10.1159/000446954] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/16/2016] [Accepted: 05/16/2016] [Indexed: 11/19/2022]
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10
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Vicario FJ, Estalella L, Hermoso J, Díaz F, Gris P. Cistoadenoma mucinoso retroperitoneal primario. Tumoración infrecuente en mujer joven. Cir Esp 2016; 94:243-5. [DOI: 10.1016/j.ciresp.2015.02.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2014] [Revised: 02/06/2015] [Accepted: 02/19/2015] [Indexed: 11/30/2022]
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Myriokefalitaki E, Luqman I, Potdar N, Brown L, Steward W, Moss EL. Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis. Arch Gynecol Obstet 2015; 293:709-20. [PMID: 26681306 DOI: 10.1007/s00404-015-3975-8] [Citation(s) in RCA: 16] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/14/2015] [Accepted: 11/24/2015] [Indexed: 11/28/2022]
Abstract
PURPOSE Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa) is a rare tumour. Prognosis and optimal management are not well established. In view of a case managed in our Centre, we performed a systematic review and meta-analysis. METHOD Systematic review of medical electronic databases for published data (1950-12/10/2015). No RCTs identified. Individual patient data detracted from case reports and case series were analysed RESULTS In total, 73 female and 5 male cases of PRMCa identified including our case. Median age at diagnosis was 42.0 years (range 18-86 years), with women being significantly younger than men at diagnosis (42.0 years versus 62.2 years, p = 0.005). A palpable abdominal mass and abdominal pain were the most common presentations in 42.9 and 23.8 % of cases, respectively. Twenty-six women were <38 years old. There were 16 women <38 years old that had surgical data reported, of which 14 underwent fertility-sparing surgery with excision of the mass. Adjuvant chemotherapy was given in 24.1 % (13/72) women. Follow-up ranged from 1 to 130 months with a median of 15 months. Of the 57 cases that had follow-up reported, recurrence occurred in 23 cases (40.4 %) within a median of 8 months from diagnosis. Median disease-free survival was 15 months (range 1-130 months). Of the women who recurred, 14 died of their disease giving 1, 2 and 5-year disease-specific survival rates of 85.9, 80.7 and 75.4 %, respectively. CONCLUSION PRMCa are rare and potentially aggressive tumours that often occur in young women. Removal of the tumour, adequate staging and adjuvant chemotherapy needs to be considered.
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Affiliation(s)
- E Myriokefalitaki
- Department of Gynaecological Oncology, University Hospitals of Leicester, Leicester, UK.
| | - I Luqman
- Department of Gynaecological Oncology, University Hospitals of Leicester, Leicester, UK
| | - N Potdar
- Department of Gynaecological Oncology, University Hospitals of Leicester, Leicester, UK
| | - L Brown
- Department of Pathology, University Hospitals of Leicester, Leicester, UK
| | - W Steward
- Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
| | - E L Moss
- Department of Gynaecological Oncology, University Hospitals of Leicester, Leicester, UK.,Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
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12
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Acharya SR, Dasgupta P, Das S, Halder S, Panda N. Retropancreatic Ovarian Tumor. Indian J Surg 2015; 78:232-4. [PMID: 27358520 DOI: 10.1007/s12262-015-1387-4] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/18/2015] [Accepted: 10/27/2015] [Indexed: 10/22/2022] Open
Abstract
Retroperitoneal mucinous cystadenomas are rare lesions (less than 50 reported) characterized by presence of ovary like stroma of unknown origin. However, germinal component of ovary has never been found in them. The pancreas occasionally gives rise to mucinous cystadenomas, but they are always intrapancreatic. We report a unique case of a rare retroperitoneal mucinous cystadenomas with presence of ovarian follicles in a 45-year-old lady who presented with an abdominal mass. This was successfully excised. Though retroperitoneal mucinous cystadenomas are rare, presence of ovarian follicle (germ cell) in them has never been reported before.
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Affiliation(s)
- Soumyo Ranjan Acharya
- Department of Surgery, R.G. Kar Medical College, P318.B.C.I.T road. Kankurgachi, Kolkata, 700054 India
| | - Prosenjit Dasgupta
- Department of Surgery, R.G. Kar Medical College, P318.B.C.I.T road. Kankurgachi, Kolkata, 700054 India
| | - Subhobroto Das
- Department of Surgery, R.G. Kar Medical College, P318.B.C.I.T road. Kankurgachi, Kolkata, 700054 India
| | - Sandip Halder
- Department of Surgery, R.G. Kar Medical College, P318.B.C.I.T road. Kankurgachi, Kolkata, 700054 India
| | - Nilanjan Panda
- Department of Surgery, R.G. Kar Medical College, P318.B.C.I.T road. Kankurgachi, Kolkata, 700054 India
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13
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Knezevic S, Ignjatovic I, Lukic S, Matic S, Dugalic V, Knezevic D, Micev M, Dragasevic S. Primary retroperitoneal mucinous cystadenoma: A case report. World J Gastroenterol 2015; 21:5427-5431. [PMID: 25954118 PMCID: PMC4419085 DOI: 10.3748/wjg.v21.i17.5427] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/16/2014] [Revised: 12/17/2014] [Accepted: 01/16/2015] [Indexed: 02/06/2023] Open
Abstract
Primary retroperitoneal mucinous cystic tumors are extremely rare. These tumors can be classified as a primary retroperitoneal mucinous cystadenoma with or without borderline malignancy or primary retroperitoneal mucinous cystadenocarcinoma. The most common of these is primary retroperitoneal mucinous cystadenoma, which almost always occurs in female patients; only ten cases have been reported in males. The most common clinical findings for this tumor type include nonspecific abdominal pain and a palpable abdominal mass. A definitive diagnosis is usually obtained from histopathology after surgical excision. Here, we report the case of a 60-year-old female patient who complained of abdominal pain that had been present for 3 mo and presented with a palpable abdominal mass. Multidetector computed tomography scanning revealed a large, unilocular cystic mass in the left retroperitoneal space. Surgical intervention was performed and the tumor was completely removed. Histopathologic examination confirmed that the tumor was a primary retroperitoneal mucinous cystadenoma. Two years after surgery, the patient remains disease free.
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14
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Kamiyama H, Shimazu A, Makino Y, Ichikawa R, Hobo T, Arima S, Nohara S, Sugiyama Y, Okumura M, Takei M, Miura H, Namekata K, Tsumura H, Okada M, Takase M, Matsumoto F. Report of a case: Retroperitoneal mucinous cystadenocarcinoma with rapid progression. Int J Surg Case Rep 2015; 10:228-31. [PMID: 25884614 PMCID: PMC4430186 DOI: 10.1016/j.ijscr.2015.04.004] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/20/2015] [Revised: 03/08/2015] [Accepted: 04/03/2015] [Indexed: 10/30/2022] Open
Abstract
INTRODUCTION Retroperitoneal mucinous cystic neoplasms are uncommon, and little is known about the etiology of the disease. Malignant forms of these are extremely rare. Here, we report a case of primary retroperitoneal mucinous cystadenocarcinoma (PRMC), which demonstrated unexpectedly aggressive progression despite finding only a limited area of adenocarcinoma. PRESENTATION OF CASE A 62-year-old woman with a complaint of abdominal discomfort was admitted to the hospital. Abdominal CT and MRI showed multiple large retroperitoneal cysts dislocating the right kidney nearly to the center of the abdomen. Transabdominal resection of the cysts was performed. Those cysts contained 1100ml of mucinous fluids in total. Cytological examination of those fluids revealed no malignant cells. The cyst wall was lined with mucinous epithelial cells, and contained some ovarian-type stroma. Also, there was a focal area of adenocarcinoma in the cyst wall, and the lesion was diagnosed as primary retroperitoneal mucinous cystadenocarcinoma. Eight months later, the patient developed lumbar bone metastasis. Chemotherapy with S-1, an oral fluoropyrimidine, and docetaxel had been begun immediately; however, the disease had rapidly spread in the retroperitoneum. Eventually, the patient died of the disease 15 months after surgery. DISCUSSION Retroperitoneal mucinous cystic neoplasms are considered to be metaplasia of embryonal coelomic epithelium. Complete excision without rupture is essential. However, variance of biological aggressiveness might exist in PRMCs. CONCLUSION Retroperitoneal mucinous cystadenocarcinoma is a rare tumor, and it is urgently necessary to elucidate the etiology of an effective therapy for the disease.
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Affiliation(s)
- Hirohiko Kamiyama
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan.
| | - Ai Shimazu
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Yurika Makino
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Ryosuke Ichikawa
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Takahiro Hobo
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Shuei Arima
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Shigeo Nohara
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Yuji Sugiyama
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Masafumi Okumura
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Masahiko Takei
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Hiroyoshi Miura
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Koji Namekata
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Hidenori Tsumura
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Motoi Okada
- Department of Pathology, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Masaru Takase
- Department of Pathology, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
| | - Fumio Matsumoto
- Department of Surgery, Koshigaya Municipal Hospital, Higashikoshigaya 10-47-1, Koshigayashi, Saitama 343-8577, Japan
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15
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Manrai M, Takesita N, Ishida H, Takashima A, Adachi T, Sasaki I, Yokokawa K, Tokuyama W, Hiruta N, Kinoshita T. Primary retroperitoneal mucinous cystic tumors with borderline malignancy: a case report and literature review. Clin Pract 2015; 5:722. [PMID: 25918634 PMCID: PMC4387346 DOI: 10.4081/cp.2015.722] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/15/2014] [Revised: 12/13/2014] [Accepted: 12/17/2014] [Indexed: 11/22/2022] Open
Abstract
Primary retroperitoneal mucinous cystic tumors with borderline malignancy are rarely encountered. To date, only 12 cases have been reported in the literature. In this report, we present an additional case. A 65-year-old nulliparous woman complained of abdominal fullness. Her medical history included a hysterectomy and a single salpingo-oophorectomy performed 25 years prior to the present event. Physical examination revealed a large cystic mass in the abdomen and pelvis. During laparotomy, a cystic tumor measuring 21×14 cm in size was observed in the left retroperitoneal space. The tumor was resected, and the final diagnosis was primary retroperitoneal mucinous cystic cancer with borderline malignancy.
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Affiliation(s)
- Megumi Manrai
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Naoki Takesita
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Hiroaki Ishida
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Akiko Takashima
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Tomohiro Adachi
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Izumi Sasaki
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Kei Yokokawa
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Wataru Tokuyama
- Department of Pathology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Nobuyuki Hiruta
- Department of Pathology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
| | - Toshihiko Kinoshita
- Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital , Chiba, Japan
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16
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Osman S, Lehnert BE, Elojeimy S, Cruite I, Mannelli L, Bhargava P, Moshiri M. A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol 2014; 42:191-208. [PMID: 24070713 DOI: 10.1067/j.cpradiol.2013.02.001] [Citation(s) in RCA: 48] [Impact Index Per Article: 4.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/13/2023]
Abstract
A clear understanding of the normal anatomy and pattern of disease spread is important in evaluating many retroperitoneal disorders. Primary retroperitoneal tumors are uncommon, accounting for 0.1%-0.2% of all malignancies in the body; 80%-90% of all primary retroperitoneal tumors are malignant. The primary retroperitoneal neoplasms can be divided into solid or cystic masses. The solid neoplasms can be classified according to their tissue of origin into 3 main categories: mesodermal tumors, neurogenic tumors, and extragonadal germ cell tumors. Computed tomography and magnetic resonance imaging play a vital role in the localization, characterization, evaluation of the extent of local invasion, assessment of metastases, and determination of treatment response for these tumors. The diagnosis of a primary retroperitoneal malignancy is often challenging owing to overlap of imaging findings. A definitive diagnosis can be established only at histopathologic analysis. However, knowledge of the important tumor characteristics, growth pattern, and vascularity can assist in narrowing the differential diagnosis.
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Affiliation(s)
- Sherif Osman
- Department of Radiology, University of Washington School of Medicine, Seattle, WA.
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17
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Spinelli C, Strambi S, Tartaglia D, Di Franco G, Pucci V, Faviana P, Lencioni M. Primary retroperitoneal müllerian adenocarcinoma: a case report and literature review. Case Rep Oncol 2013; 6:616-21. [PMID: 24474926 PMCID: PMC3901585 DOI: 10.1159/000357424] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/19/2022] Open
Abstract
Primary retroperitoneal müllerian adenocarcinoma (PRMA) is an extremely rare clinical entity. We report the case of a 54-year-old woman who presented with a mass in the right lower retroperitoneum, identified during an ultrasound exam. Computed tomography confirmed a retroperitoneal mass measuring 11 cm. The patient underwent laparotomy and the mass was completely excised. The histopathological exam revealed PRMA.
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Affiliation(s)
- C Spinelli
- Department of Surgical, Clinical, Molecular Pathology and Critical Area, UO Chirurgia Generale 2, University of Pisa, Pisa, Italy
| | - S Strambi
- Department of Surgical, Clinical, Molecular Pathology and Critical Area, UO Chirurgia Generale 2, University of Pisa, Pisa, Italy
| | - D Tartaglia
- Department of Surgical, Clinical, Molecular Pathology and Critical Area, UO Chirurgia Generale 2, University of Pisa, Pisa, Italy
| | - G Di Franco
- Department of Surgical, Clinical, Molecular Pathology and Critical Area, UO Chirurgia Generale 2, University of Pisa, Pisa, Italy
| | - V Pucci
- Department of Surgical, Clinical, Molecular Pathology and Critical Area, UO Chirurgia Generale 2, University of Pisa, Pisa, Italy
| | - P Faviana
- Department of Surgical, Clinical, Molecular Pathology and Critical Area, UO Anatomia Patologica 3, University of Pisa, Pisa, Italy
| | - M Lencioni
- Department of Oncology, Transplants, and New Technologies, UO Oncologia 1, University of Pisa, Pisa, Italy
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18
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Karakurt O, Kaplan T, Gunal N, Gulbahar G, Kocer B, Han S, Dural K, Sakinci U. Elastofibroma dorsi management and outcomes: review of 16 cases. Interact Cardiovasc Thorac Surg 2013; 18:197-201. [PMID: 24218496 DOI: 10.1093/icvts/ivt442] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022] Open
Abstract
OBJECTIVES Elastofibroma dorsi (ED) is a rare, benign lesion arising from connective tissue, usually found at the inferior pole of the scapula. To date, only a few small series have been reported in the English literature and there are few data about the long-term outcomes after surgery. Our goal is to contribute a better understanding of this tumour and to determine the long-term outcomes after surgery. METHODS Sixteen patients with a diagnosis of ED were identified from the unit's database. The clinical presentation, diagnosis, pathological evidences and long-term outcomes were evaluated. RESULTS There were 11 females and 5 males with a mean age of 61.1 years (range 38-78 years). The tumour was located on the right in 5 (31.2%) patients, on the left in 6 (37.5%) patients and bilaterally in 5 (31.2%). Six patients had painful scapular swelling resulting in restriction of movement of the shoulder whereas 10 reported only painful scapular mass. All 16 patients underwent complete resections. The tumour size ranged from 3 to 15 cm. The mean hospital stay was 3.1 ± 1.4 days with a morbidity of 18.75% (seroma observed in 3 patients). The mean follow-up was 58.4 ± 29.5 months (range 11-92 months). In 2 patients (12.5%) a new occurrence on the contralateral side was observed at the follow-up. CONCLUSIONS Elastofibroma dorsi is a rare, ill-defined, pseudotumoural lesion of the soft tissues. Surgical treatment can be proposed if the lesion is symptomatic. Furthermore, at the follow-up, the possibility of new occurrences on the contralateral side should be kept in mind.
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Affiliation(s)
- Ozgur Karakurt
- Department of Thoracic Surgery, Ankara Numune Teaching and Research Hospital, Ankara, Turkey
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19
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Falidas E, Konstandoudakis S, Vlachos K, Archontovasilis F, Mathioulakis S, Boutzouvis S, Villias C. Primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient. Case report and review of the literature. World J Surg Oncol 2011; 9:98. [PMID: 21871118 PMCID: PMC3177882 DOI: 10.1186/1477-7819-9-98] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2010] [Accepted: 08/27/2011] [Indexed: 12/23/2022] Open
Abstract
BACKGROUND Primary retroperitoneal mucinous cystadenoma of borderline malignancy represents a rare tumor, with unclear histogenesis, concerning almost exclusively women. Only two cases concerning male patients have been reported. CASE REPORT We herein report a case of a 37 year old man undergone laparotomy for a sizable retroperitoneal tumor resulting after the histological examination to a primary retroperitoneal mucinous cystadenoma of borderline malignancy. CONCLUSION This is the third case of primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient reported in the literature. The preoperative diagnosis is impossible. Laparotomy constitutes the only diagnostic and curative approach.
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Affiliation(s)
- Evangelos Falidas
- 1st Department of General Surgery, 417 NIMTS, Veterans Hospital of Athens, Monis Petraki 10-12, Athens, 11521, Greece.
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20
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Jiang H, Jin K, You Q, Fang W, Xu N. Retroperitoneal primary mucinous adenocarcinoma: A case report. Oncol Lett 2011; 2:633-636. [PMID: 22848240 DOI: 10.3892/ol.2011.319] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/23/2011] [Accepted: 05/12/2011] [Indexed: 11/06/2022] Open
Abstract
Retroperitoneal primary mucinous adenocarcinoma (RPMA) is extremely rare and the histogenesis of this tumor remains unclear. There is no consensus on the appropriate treatment for RPMA. Surgical resection is standard for the treatment of RPMA, whereas the benefits of chemotherapy with regard to this tumor remain to be established. This case report concerns a 21-year-old female individual with RPMA. The patient initially presented with chronic lower back pain and weight loss. Additionally, carcinoembryonic antigen (CEA) levels were found to be elevated. A computed tomography scan revealed a mass in the abdominal cavity. Consequently, laparotomy was performed, which revealed a well-defined tumor in the right retroperitoneum. Chemotherapy as a monotherapy was not considered as a viable treatment option. Therefore, the patient was initially administered a combined treatement of oxaliplatin and 5-fluorouracil. This treatment was then changed to paclitaxel and 5-fluorouracil. Findings showed a decrease in the CEA serum levels, indicating that this combination treatment may be efficacious in the treatment of RPMA since local recurrence following surgical resection was well controlled with chemotherapy.
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Affiliation(s)
- Haiping Jiang
- Department of Internal Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou
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21
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Primary retroperitoneal mucinous cystadenocarcinoma in a male patient: a case report. CASES JOURNAL 2009; 2:7196. [PMID: 19918513 PMCID: PMC2769343 DOI: 10.4076/1757-1626-2-7196] [Citation(s) in RCA: 13] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/12/2009] [Accepted: 07/23/2009] [Indexed: 12/26/2022]
Abstract
In the literature, 51 cases of primary retroperitoneal mucinous cystadenocarcinoma have been published. We report the fourth case occurring in a male patient. The 42-year-old patient presented with multiple retroperitoneal cystic masses causing abdominal discomfort without alteration of the global clinical state. The masses were totally removed by a two-stage surgery. No other treatment has been introduced. After a follow-up of 6 months, the patient is disease-free. This rare tumor most likely arises from the mucinous metaplasia of peritoneal inclusion cysts rather than from ectopic ovarian tissue or ovarian teratomas. The occurrence of such a tumor in a male patient supports this theory. Preoperative diagnosis is mostly difficult. Clinical behavior and treatment are still controversial.
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22
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A unique benign mucinous cystadenoma of the retroperitoneum: a case report and review of the literature. Arch Gynecol Obstet 2009; 281:167-9. [PMID: 19449022 DOI: 10.1007/s00404-009-1118-9] [Citation(s) in RCA: 13] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2008] [Accepted: 04/29/2009] [Indexed: 10/20/2022]
Abstract
Primary retroperitoneal mucinous cysts are rare. Most often malignant, lesions present on a spectrum, fitting the histopathological categories of benign, borderline and malignant. The rarest form is the benign mucinous cystadenoma adenocarcinoma, of which only 20 cases have been reported. We present here the curious case of a 37-year-old woman with two large, fast growing, cystic, benign, primary retroperitoneal mucinous cystadenomas treated definitively by local resection.
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23
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Moral González M, García-Blanch de Benito G, Sánchez Gil A, Díaz García GA, Cuberes Monserrat R. [Primary retroperitoneal mucinous cystadenocarcinoma]. Cir Esp 2008; 84:169-71. [PMID: 18783679 DOI: 10.1016/s0009-739x(08)72162-6] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/21/2022]
Affiliation(s)
- María Moral González
- Servicio de Cirugía General y del Aparato Digestivo, Hospital de Móstoles, Móstoles Madrid, España.
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24
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Youssef C, Mathelin C, Guerin C, Roy C, Walter P, Rodriguez B, Brettes JP. Primary retroperitoneal endometrial cystadenocarcinoma presenting as pelvic abscess on ultrasound. ULTRASOUND IN OBSTETRICS & GYNECOLOGY : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF ULTRASOUND IN OBSTETRICS AND GYNECOLOGY 2008; 31:714-715. [PMID: 18504785 DOI: 10.1002/uog.5342] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/26/2023]
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25
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Lee SA, Bae SH, Ryoo HM, Jung HY, Jang SB, Kum YS. Primary retroperitoneal mucinous cystadenocarcinoma: a case report and review of the literature. Korean J Intern Med 2007; 22:287-91. [PMID: 18309690 PMCID: PMC2687666 DOI: 10.3904/kjim.2007.22.4.287] [Citation(s) in RCA: 16] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/27/2022] Open
Abstract
Primary retroperitoneal mucinous cystadenocarcinoma is a rare tumor. Only about 30 such cases have been reported in the worldwide literature, and a few Korean cases have been reported. The pathogenesis is not clear, and coelomic metaplasia of the retroperitoneal mesothelium has gained wide support. There is no consensus on the appropriate treatment, but surgical exploration is needed for the diagnosis and treatment, and adjuvant chemotherapy may be recommended following complete surgical excision. The long-term prognosis has not been established. We report here on a 32-year-old woman who was diagnosed as having a retroperitoneal mucinous cystadenocarcinoma with mural nodules of sarcomatoid change. Tumor excision and adjuvant chemotherapy were done and the patient is doing well without any evidence of recurrence at 42 months postoperatively.
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Affiliation(s)
- Sun Ah Lee
- Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
| | - Sung Hwa Bae
- Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
| | - Hun Mo Ryoo
- Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
| | - Hyun Young Jung
- Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
| | - Saet Byul Jang
- Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
| | - Yoon Seup Kum
- Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea
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26
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Tjalma WAA, Vaneerdeweg W. Primary retroperitoneal mucinous cystadenocarcinomas are a distinct entity. Int J Gynecol Cancer 2007; 18:184-8. [PMID: 17506841 DOI: 10.1111/j.1525-1438.2007.00981.x] [Citation(s) in RCA: 12] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/05/2023] Open
Abstract
Primary retroperitoneal mucinous cystadenocarcinomas are rare tumors with a controversial pathogenesis. Present report describes a 74-year-old woman with a retroperitoneal cystic pelvic mass. Her past medical history included appendectomy, bilateral salpingo-oophorectomy, and a hysterectomy. An explorative laparotomy was performed and the mass was completely excised. Definitive pathology revealed a primary retroperitoneal mucinous cystadenocarcinoma of the ovarian type. Further management consisted of four cycles carboplatin. She had a recurrence after 8 months and died 31 months after the initial diagnosis. Primary retroperitoneal mucinous cystadenocarcinomas are distinct entity, with the same poor prognosis as their ovarian counterpart.
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Affiliation(s)
- W A A Tjalma
- Department of Gynecological Oncology, University Hospital Antwerp, Antwerp, Belgium.
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